A
Amarjit S. Chaudhry
Researcher at St. Jude Children's Research Hospital
Publications - 19
Citations - 738
Amarjit S. Chaudhry is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Pregnane X receptor & Constitutive androstane receptor. The author has an hindex of 17, co-authored 19 publications receiving 606 citations. Previous affiliations of Amarjit S. Chaudhry include Pfizer & Centre for Addiction and Mental Health.
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Journal ArticleDOI
Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
Timothy S. Tracy,Amarjit S. Chaudhry,Bhagwat Prasad,Kenneth E. Thummel,Erin G. Schuetz,Xiao-bo Zhong,Yun Chen Tien,Hyunyoung Jeong,Xian Pan,Laura M. Shireman,Jessica Tay-Sontheimer,Yvonne S. Lin +11 more
TL;DR: The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human drug metabolism and the potential utility of endogenous probe compounds to assess rates of drug metabolism among individuals is described.
Journal ArticleDOI
Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.
Henriette E. Meyer zu Schwabedissen,Henriette E. Meyer zu Schwabedissen,Kerstin Böttcher,Amarjit S. Chaudhry,Heyo K. Kroemer,Erin G. Schuetz,Richard B. Kim,Richard B. Kim +7 more
TL;DR: OATP1B1 transcriptional regulation is under dual nuclear receptor control through the oxysterol sensing LXRα and the bile acid sensor FXR and may play an important and heretofore unrecognized role during cholestasis, drug‐induced liver injury, and OATP 1B1 induction–related drug interactions.
Journal ArticleDOI
Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.
Yoshiyuki Shirasaka,Amarjit S. Chaudhry,Matthew G. McDonald,Bhagwat Prasad,Timothy C. Wong,Justina C. Calamia,Alison E. Fohner,Timothy A. Thornton,Nina Isoherranen,Jashvant D. Unadkat,Allan E. Rettie,Erin G. Schuetz,Ken Thummel +12 more
TL;DR: It is demonstrated that interindividual variability in CYP2C19 activity is due to differences in both CYP 2C19 protein content associated with gene diplotypes and the POR concentration.
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Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability
Zhican Wang,Timothy C. Wong,Takanori Hashizume,Leslie J. Dickmann,Michele Scian,Nicholas J. Koszewski,Jesse P. Goff,Ronald L. Horst,Amarjit S. Chaudhry,Erin G. Schuetz,Kenneth E. Thummel +10 more
TL;DR: The presence of 25OHD3-3-glucuronide in both human plasma and bile was confirmed, suggesting that the glucuronidation pathway might be physiologically relevant and contribute to vitamin D homeostasis in humans.
Journal ArticleDOI
CYP2C9*1B Promoter Polymorphisms, in Linkage with CYP2C19*2, Affect Phenytoin Autoinduction of Clearance and Maintenance Dose
Amarjit S. Chaudhry,Thomas J. Urban,Jatinder K. Lamba,Angela K. Birnbaum,Rory P. Remmel,Murali Subramanian,Stephen C. Strom,Joyce H. S. You,Dalia Kasperaviciute,Claudia B. Catarino,Rodney A. Radtke,Sanjay M. Sisodiya,David Goldstein,Erin G. Schuetz +13 more
TL;DR: CYP2C9 rPMs affect phenytoin-dependent induction of CYP1C9 and pheny toin metabolism in humans, with an effect size comparable with that for CYP2 C9*2 and 2C9*3.