J
Jatinder K. Lamba
Researcher at University of Florida
Publications - 146
Citations - 9942
Jatinder K. Lamba is an academic researcher from University of Florida. The author has contributed to research in topics: Myeloid leukemia & Gene. The author has an hindex of 42, co-authored 130 publications receiving 9177 citations. Previous affiliations of Jatinder K. Lamba include St. Jude Children's Research Hospital & Indian Council of Medical Research.
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Journal ArticleDOI
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
Peter M. Kuehl,Jiong Zhang,Yvonne S. Lin,Jatinder K. Lamba,Mahfoud Assem,John D. Schuetz,Paul B. Watkins,Ann K. Daly,Steven A. Wrighton,Stephen D. Hall,Patrick Maurel,Mary V. Relling,Cynthia Brimer,Kazuto Yasuda,Raman Venkataramanan,Stephen C. Strom,Kenneth E. Thummel,Mark S. Boguski,Erin G. Schuetz +18 more
TL;DR: CYP3A5 was more frequently expressed in livers of African Americans than in those of Caucasians, and may be the most important genetic contributor to interindividual and interracial differences in CYP3A-dependent drug clearance and in responses to many medicines.
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Genetic contribution to variable human CYP3A-mediated metabolism
TL;DR: The human CYP3A subfamily plays a dominant role in the metabolic elimination of more drugs than any other biotransformation enzyme and may be implicated in disease risk and the metabolism of endogenous steroids or xenobiotics in these tissues.
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Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism.
Yvonne S. Lin,Amy L. S. Dowling,Sean D. Quigley,Federico M. Farin,Jiong Zhang,Jatinder K. Lamba,Erin G. Schuetz,Kenneth E. Thummel +7 more
TL;DR: CYP3A4 and CYP3A5 genes share a common regulatory pathway for constitutive expression, possibly involving conserved elements in the 5'-flanking region.
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Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.
Vishal Lamba,Jatinder K. Lamba,Kazuto Yasuda,Stephen C. Strom,Julio C. Davila,Michael L. Hancock,James D. Fackenthal,Peter K. Rogan,Barbara J. Ring,Steven A. Wrighton,Erin G. Schuetz +10 more
TL;DR: The 1459C>T SNP, which resulted in the Arg487Cys substitution, was associated with the lowest level of CYP2B6 activity in livers of females, and several common SNPs that are associated with polymorphic CYP 2B6 expression were found.
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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.
Erin G. Schuetz,Stephen C. Strom,Kazuto Yasuda,Valerie Lecureur,Mahfoud Assem,Cynthia Brimer,Jatinder K. Lamba,Richard B. Kim,Vinod Ramachandran,Bernard J. Komoroski,Raman Venkataramanan,Hongbo Cai,Christopher J. Sinal,Frank J. Gonzalez,John D. Schuetz +14 more
TL;DR: Enhanced hepatocellular concentrations of bile acids, due to the down-regulation of BSEP/SPGP-mediated efflux in FXR nullizygous mice, result in an alternate but apparent compensatory up- regulation of CYP3A, CYP2B, and some ABC transporters that is consistent with activation of PXR/SXR by bile acid.