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Amélie Descheemaeker
Researcher at University of Auvergne
Publications - 9
Citations - 85
Amélie Descheemaeker is an academic researcher from University of Auvergne. The author has contributed to research in topics: Allodynia & Isosorbide dinitrate. The author has an hindex of 4, co-authored 7 publications receiving 65 citations. Previous affiliations of Amélie Descheemaeker include French Institute of Health and Medical Research.
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Neuropathic pain depends upon D-serine co-activation of spinal NMDA receptors in rats.
Yan Lefèvre,Aurélie Amadio,Peggy Vincent,Amélie Descheemaeker,Stéphane H. R. Oliet,Radhouane Dallel,Daniel L. Voisin +6 more
TL;DR: Results show that neuropathic pain depends upon glial d-serine that co-activates spinal NMDA receptors and that upregulated serine racemase expression was upregulated in astrocyte processes in neuropathic rats compared to sham rats.
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Recurrent administration of the nitric oxide donor, isosorbide dinitrate, induces a persistent cephalic cutaneous hypersensitivity: A model for migraine progression
Radhouane Dallel,Amélie Descheemaeker,Amélie Descheemaeker,Philippe Luccarini,Philippe Luccarini +4 more
TL;DR: Repeated ISDN administration appears to be a naturalistic rat model for migraine progression, suitable for screening acute and preventive migraine therapies, and suggests frequent and severe migraine attacks associated with allodynia may be a risk factor for disease progression.
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Activation of medullary dorsal horn γ isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia.
TL;DR: The findings suggest that PKCγ activation, without any other experimental manipulation, is sufficient for the development of static and dynamic mechanical allodynia.
Journal ArticleDOI
The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn.
José María Flores Ramos,Laurent Devoize,Amélie Descheemaeker,Jean-Louis Molat,Philippe Luccarini,Radhouane Dallel +5 more
TL;DR: It is demonstrated that a nitric oxide donor, isosorbide dinitrate, induces selectively cephalic hyperalgesia that arises as a consequence of central sensitization in pain pathways that subserve meningeal nociception.
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Dual enkephalinase inhibitor PL37 as a potential novel treatment of migraine: evidence from a rat model.
Amélie Descheemaeker,Hervé Poras,Michel Wurm,Philippe Luccarini,Tanja Ouimet,Radhouane Dallel +5 more
TL;DR: Daily oral administration of PL37 prevented cephalic mechanical hypersensitivity and decreased touch-induced c-Fos expression in trigeminocervical complex following repeated isosorbide dinitrate administration reveal the therapeutic potential of the dual enkephalinase inhibitors as an acute and prophylactic treatment for migraine.