Amina Sadiq

TL;DR: Activity of 4-thioflavones and 4-iminoflavones was found to be higher than that of their corresponding flavone analogues and the presence of electronegative groups in the studied compounds showed a direct relationship to the antibacterial activity.

TL;DR: This review article is oriented to provide an insight and a deeper understanding of the tyrosinase inhibitory activity of an array of natural and bioinspired phenolic compounds with special emphasis on flavonoids to demonstrate how the position of ring substituents and their interaction with tyosinase could be correlated with their effectiveness or lack thereof against inhibiting the enzyme.

TL;DR: A library of new intriguing flavonol derivatives was designed and synthesized through a facile route involving Algar-Flynn-Oyamada reaction in a one-pot synthesis and showed that some compounds are in a linear correlation with Lipinski's rule of five demonstrating good drug-likeness and bioactivity score for drug targets.

TL;DR: The use of 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) is the most widely used quinone with a high reduction potential, and it commonly mediates hydride transfer reactions as discussed by the authors.

TL;DR: The prime objective of this research work is to prepare readily soluble synthetic analogues of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various substituents on biological properties of synthetic compounds and displayed that most of the derivatives were potent inhibitors of acetylcholinesterase and butyrylcholinease with varying degree of IC50 values.