Catalyst-free reactions developed during the last decade and the latest developments in this emerging field are summarized with a focus on catalyst-free reactions in-water and on-water. Various named reactions, multi-component reactions and the synthesis of heterocyclic compounds are discussed including the use of various energy input systems such as microwave- and ultrasound irradiation, among others. Organic chemists and the practitioners of this art both in academia and industry hopefully will continue to design benign methodologies for organic synthesis in aqueous media under catalyst-free conditions by using alternative energy inputs based on fundamental principles.

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

http://www.chtf.stuba.sk/~szolcsanyi/education/files/Chemia%20heterocyklickych%20zlucenin/Prednaska%203/Doplnkove%20studijne%20materialy/Recent%20developments%20and%20biological%20activities%20of%20thiazolidinone%20derivatives%20-%20A%20review.pdf

Recent developments and biological activities of thiazolidinone derivatives: A review

Mesoionic carbenes are a subclass of the family of N-heterocyclic carbenes that generally feature less heteroatom stabilization of the carbenic carbon and hence impart specific donor properties and

Mesoionic and Related Less Heteroatom-Stabilized N-Heterocyclic Carbene Complexes: Synthesis, Catalysis, and Other Applications.

Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications.

4-Thiazolidinones: the advances continue….

4-Thiazolidinone – A biologically active scaffold

https://refubium.fu-berlin.de/bitstream/fub188/15538/1/c5cc05506g.pdf

Triply cyclometalated trinuclear iridium(III) and trinuclear palladium(II) complexes with a tri-mesoionic carbene ligand

Complexes of mesoionic carbene (MIC) ligands are gaining immense popularity in organometallic chemistry and homogeneous catalysis. We present here a series of palladium(II) complexes that are comprised of MIC donor ligands, and we demonstrate their applications in α-arylation, α-methylation, and Suzuki–Miyaura coupling reactions. All the complexes have been structurally characterized by X-ray crystallographic analysis. These palladium(II) complexes are potent precatalysts and they deliver good to excellent yields for both α-arylation and Suzuki–Miyaura coupling reactions. A palladium(II) complex bearing two MIC units in a trans fashion is used for chemoselective Suzuki–Miyaura coupling reaction. This complex delivers lower yields in α-arylation reactions compared with PEPPSI-type complexes, however, it gives an α-methylated product when the reaction is conducted in N,N-dimethylformamide. Mercury poisoning experiments suggest that the Suzuki–Miyaura coupling reaction likely proceeds via Pd nanoparticles. However, the α-arylation reaction proceeds homogeneously, as shown by the negative mercury poison test. The present results thus open up new avenues for MIC ligands in catalytic α-arylation and α-methylation reactions.

Palladium Complexes Bearing Mesoionic Carbene Ligands: Applications in α-Arylation, α-Methylation and Suzuki–Miyaura Coupling Reactions

The diversity in the biological response of 4-thiazolidinones has attracted the attention of many researchers to explore this framework for its potential. It is, therefore, of prime importance that the study of this topic and the development of new synthetic strategies should be based on the most recent knowledge, emerging from the latest research. This review is an endeavor to highlight the progress in the chemistry and biological activity of the 4-thiazolidinones, predominantly after 2006. The last section of the review encompasses the various patents granted on 4-thiazolidinone analogs/derivatives with World Intellectual Proprietary Organization (WIPO) and United State Patent Trademark Office (USPTO), particularly in the duration of the year 2000 to the year 2012.

Amit Verma

Papers

4-Thiazolidinone – A biologically active scaffold

4-Thiazolidinones: the advances continue….

Triply cyclometalated trinuclear iridium(III) and trinuclear palladium(II) complexes with a tri-mesoionic carbene ligand

Palladium Complexes Bearing Mesoionic Carbene Ligands: Applications in α-Arylation, α-Methylation and Suzuki–Miyaura Coupling Reactions

4-Thiazolidinones: The Advances Continue...