A
Amkele Ngomti
Researcher at University of Cape Town
Publications - 2
Citations - 91
Amkele Ngomti is an academic researcher from University of Cape Town. The author has contributed to research in topics: Vaccination & Immunogenicity. The author has an hindex of 2, co-authored 2 publications receiving 5 citations.
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Journal ArticleDOI
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner.
Roanne Keeton,Simone I. Richardson,Simone I. Richardson,Thandeka Moyo-Gwete,Thandeka Moyo-Gwete,Tandile Hermanus,Tandile Hermanus,Marius Belmondo Tincho,Ntombi Benede,Nelia P. Manamela,Nelia P. Manamela,Richard Baguma,Zanele Makhado,Zanele Makhado,Amkele Ngomti,Thopisang Motlou,Thopisang Motlou,Mathilda Mennen,Lionel Chinhoyi,Sango Skelem,Hazel Maboreke,Deelan Doolabh,Arash Iranzadeh,Ashley Otter,Tim Brooks,Mahdad Noursadeghi,James C. Moon,James C. Moon,Alba Grifoni,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Jonathan M. Blackburn,Nei yuan Hsiao,Carolyn Williamson,Catherine Riou,Ameena Ebrahim Goga,Nigel Garrett,Nigel Garrett,Linda-Gail Bekker,Glenda Gray,Ntobeko A B Ntusi,Penny L. Moore,Penny L. Moore,Wendy A. Burgers +44 more
TL;DR: In this article, the effect of prior infection with different SARS-CoV-2 variants on Ad26.COV2.S immunogenicity was examined, showing that prior infection significantly boosts spike-binding antibodies, antibody-dependent cellular cytotoxicity, and neutralizing antibodies against D614G, Beta, and Delta.
Posted ContentDOI
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant dependent manner
Roanne Keeton,Simone I. Richardson,Simone I. Richardson,Thandeka Moyo-Gwete,Thandeka Moyo-Gwete,Tandile Hermanus,Tandile Hermanus,Marius Belmondo Tincho,Ntombi Benede,Nelia P. Manamela,Nelia P. Manamela,Richard Baguma,Zanele Makhado,Zanele Makhado,Amkele Ngomti,Thopisang Motlou,Thopisang Motlou,Mathilda Mennen,Lionel Chinhoyi,Sango Skelem,Hazel Maboreke,Deelan Doolabh,Arash Iranzadeh,Ashley Otter,Tim Brooks,Mahdad Noursadeghi,James C. Moon,James C. Moon,Jonathan M. Blackburn,Nei-yuan Hsiao,Carolyn Williamson,Catherine Riou,Ameena Ebrahim Goga,Nigel Garrett,Nigel Garrett,Linda-Gail Bekker,Glenda Gray,Ntobeko A B Ntusi,Penny L. Moore,Penny L. Moore,Wendy A. Burgers +40 more
TL;DR: The effect of prior infection with ancestral (D614G) or Beta variants on Ad26.COV2.S immunogenicity was examined in this article, showing that prior exposure from infection significantly increased the magnitude of spike binding antibodies, neutralizing antibodies and antibody-dependent cellular cytotoxicity activity (ADCC) against D614G, Beta and Delta variants.