Amruta Jambekar

TL;DR: Results show that in the SOD1(G93A) model of neurodegenerative diseases, the concentration of brain glutamate can be lowered by inhibiting in vivo the synthesis of glutamine with non-toxic doses of MSO.

TL;DR: Comparisons between ATPase activity at maximum Ca2+ concentrations and conformational changes in TnC measured using a fluorescent probe provide evidence that different substitutions perturb the structure of the regulatory complex in different ways.

TL;DR: This study has shown that acute liver failure can be induced in mice by administering Escherichia coli lipopolysaccharide and D‐galactosamine, which induce an inflammatory response involving tumour necrosis factor (TNF)‐α production and a hepatocyte‐specific transcriptional block.

TL;DR: In this article, the authors examined seven mutant tropomyosins, E62Q, D84N, I172T, L185R, S215L, D230N, and M281T, to determine how the biochemical characteristics of each mutant proteins are altered, which in turn could provide a structural rationale for treatment of the cardiomyopathies they produce.

TL;DR: The L,R isomer of MSO, which does not inhibit glutamine synthetase and was previously thought to be inert, both significantly reduced IL-6 secretion in isolated macrophages and increased survival in a mouse model for inflammatory liver failure.