M
Margaret S. Sunitha
Researcher at National Centre for Biological Sciences
Publications - 13
Citations - 459
Margaret S. Sunitha is an academic researcher from National Centre for Biological Sciences. The author has contributed to research in topics: Myosin & Myosin head. The author has an hindex of 8, co-authored 13 publications receiving 337 citations. Previous affiliations of Margaret S. Sunitha include Tata Institute of Fundamental Research.
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Journal ArticleDOI
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
Suman Nag,Darshan V. Trivedi,Saswata S. Sarkar,Arjun S. Adhikari,Margaret S. Sunitha,Shirley Sutton,Kathleen M. Ruppel,James A. Spudich +7 more
TL;DR: It is proposed that hypercontractility is due to an increase in the number of myosin heads (S1) that are accessible for force production and that phosphorylation of either S1 or MyBP-C weakens these interactions.
Journal ArticleDOI
Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation.
Julian R. Homburger,Eric M. Green,Colleen Caleshu,Margaret S. Sunitha,Rebecca E. Taylor,Kathleen M. Ruppel,Raghu Metpally,Steven D. Colan,Michelle Michels,Sharlene M. Day,Iacopo Olivotto,Carlos Bustamante,Frederick Dewey,Carolyn Y. Ho,James A. Spudich,Euan A. Ashley +15 more
TL;DR: This study combines structural models of myosin from multiple stages of its chemomechanical cycle, exome sequencing data from two population cohorts of 60,706 and 42,930 individuals, and genetic and phenotypic data from 2,913 patients with HCM to identify regions of disease enrichment within β-cardiac myOSin.
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Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties.
Atul Kumar Upadhyay,Anita Chacko,A. Gandhimathi,Pritha Ghosh,K. Harini,Agnel Praveen Joseph,Adwait G. Joshi,Adwait G. Joshi,Snehal D. Karpe,Swati Kaushik,Nagesh A. Kuravadi,Chandana Shankara Lingu,Jarjapu Mahita,Ramya Malarini,Sony Malhotra,Manoharan Malini,Oommen K. Mathew,Oommen K. Mathew,Eshita Mutt,Mahantesha B.N. Naika,Sathyanarayanan Nitish,Shaik Naseer Pasha,Shaik Naseer Pasha,Upadhyayula S. Raghavender,Anantharamanan Rajamani,S Shilpa,Prashant Shingate,Prashant Shingate,Heikham Russiachand Singh,Anshul Sukhwal,Anshul Sukhwal,Margaret S. Sunitha,Manojkumar Sumathi,S. Ramaswamy,Malali Gowda,Ramanathan Sowdhamini +35 more
TL;DR: The availability of the whole genome of O.tenuiflorum and the sequence analysis suggests that small amino acid changes at the functional sites of genes involved in metabolite synthesis pathways confer special medicinal properties to this herb.
Journal ArticleDOI
Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies *
Tejas M. Gupte,F. Haque,Binnu Gangadharan,Margaret S. Sunitha,Souhrid Mukherjee,Swetha Anandhan,Deepa Selvi Rani,Namita Mukundan,Amruta Jambekar,Kumarasamy Thangaraj,Ramanathan Sowdhamini,Ruth F. Sommese,Suman Nag,James A. Spudich,John A. Mercer +14 more
TL;DR: Comparisons between ATPase activity at maximum Ca2+ concentrations and conformational changes in TnC measured using a fluorescent probe provide evidence that different substitutions perturb the structure of the regulatory complex in different ways.
Journal ArticleDOI
Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region.
Binnu Gangadharan,Binnu Gangadharan,Margaret S. Sunitha,Souhrid Mukherjee,Ritu Roy Chowdhury,F. Haque,Narendrakumar Sekar,Ramanathan Sowdhamini,James A. Spudich,John A. Mercer +9 more
TL;DR: The primary reason by which these TNNT2 mutations between residues 92 and 144 cause cardiomyopathy is by changing the affinity of TnT for Tm within the TNT1 region, according to the modeled structure of TNT1 and its interactions with Tm.