Amy Hacker-Prietz

TL;DR: It is demonstrated that purified B. fragilis toxin up-regulates SMO in HT29/c1 and T84 colonic epithelial cells, resulting in SMO-dependent generation of ROS and induction of γ-H2A.x, a marker of DNA damage, which indicates that SMO is a source of bacteria-induced ROS directly associated with tumorigenesis and could serve as a unique target for chemoprevention.

TL;DR: This phase 2 multi‐institutional study was designed to determine whether gemcitabine with fractionated stereotactic body radiotherapy (SBRT) results in acceptable late grade 2 to 4 gastrointestinal toxicity when compared with a prior trial of GEM with single‐fraction SBRT in patients with locally advanced pancreatic cancer (LAPC).

TL;DR: SBRT is associated with significantly less severe RIL than CRT at 1 month in LAPC, suggesting that radiation technique affects RIL and supporting previous modeling studies.

TL;DR: Chemotherapy followed by SBRT in patients with locally advanced and borderline resectable pancreatic cancer resulted in minimal acute and late toxicity and a large proportion of patients underwent surgical resection despite limited radiographic response to therapy.

TL;DR: Pre-SBRT MTV and TLG are potential predictive factors for overall survival in patients with LAPC and may assist in tailoring therapy.