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Daniel A. Laheru
Researcher at Johns Hopkins University School of Medicine
Publications - 83
Citations - 7344
Daniel A. Laheru is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 25, co-authored 83 publications receiving 5635 citations. Previous affiliations of Daniel A. Laheru include Howard Hughes Medical Institute & Thomas Jefferson University.
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Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer
Christine A. Iacobuzio-Donahue,Baojin Fu,Shinichi Yachida,Mingde Luo,Hisashi Abe,Clark M. Henderson,Felip Vilardell,Zheng Wang,Jesse Keller,Priya Banerjee,Joseph M. Herman,John L. Cameron,Charles J. Yeo,Marc K. Halushka,James R. Eshleman,Marian Raben,Alison P. Klein,Ralph H. Hruban,Manuel Hidalgo,Daniel A. Laheru +19 more
TL;DR: Pancreatic cancers are represented by distinct genetic subtypes with significantly different patterns of failure, and determinations of DPC4 status at initial diagnosis may be of value in stratifying patients into treatment regimens related to local control versus systemic therapy.
Journal ArticleDOI
PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers.
Mark Yarchoan,Lee A. Albacker,Alexander Hopkins,Meagan Montesion,Karthikeyan Murugesan,Teena Vithayathil,Neeha Zaidi,Nilofer S. Azad,Daniel A. Laheru,Garrett M. Frampton,Elizabeth M. Jaffee +10 more
TL;DR: The results indicate that PD-L1 expression and TMB may each inform the use of ICIs, point to different mechanisms by which PD- L1 expression regulates ICI responsiveness, and identify new opportunities for therapeutic development.
Journal ArticleDOI
Survival in Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy and Surgical Resection
Georgios Gemenetzis,Vincent P. Groot,Alex B. Blair,Daniel A. Laheru,Lei Zheng,Amol Narang,Elliot K. Fishman,Ralph H. Hruban,Jun Yu,Richard A. Burkhart,John L. Cameron,Matthew J. Weiss,Christopher L. Wolfgang,Jin He +13 more
TL;DR: Surgical resection of LAPC after neoadjuvant therapy is feasible in a highly selected cohort of patients (20%) and is associated with significantly longer median overall survival.
Journal ArticleDOI
Lymphocyte-Sparing Effect of Stereotactic Body Radiation Therapy in Patients With Unresectable Pancreatic Cancer
Aaron T. Wild,Joseph M. Herman,Avani S. Dholakia,Shalini Moningi,Yao Lu,Lauren M. Rosati,Amy Hacker-Prietz,Ryan Assadi,Ali M. Saeed,Timothy M. Pawlik,Elizabeth M. Jaffee,Daniel A. Laheru,Phuoc T. Tran,Matthew J. Weiss,Christopher L. Wolfgang,Eric C. Ford,Stuart A. Grossman,Xiaobu Ye,Susannah G. Ellsworth +18 more
TL;DR: SBRT is associated with significantly less severe RIL than CRT at 1 month in LAPC, suggesting that radiation technique affects RIL and supporting previous modeling studies.