R
Robert A. Casero
Researcher at Johns Hopkins University School of Medicine
Publications - 274
Citations - 17436
Robert A. Casero is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Polyamine & Spermine. The author has an hindex of 68, co-authored 253 publications receiving 15681 citations. Previous affiliations of Robert A. Casero include Wayne State University & Eugene Applebaum College of Pharmacy and Health Sciences.
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Journal Article
DPC4 Gene in Various Tumor Types
Mieke Schutte,Ralph H. Hruban,Lora Hedrick,Kathleen R. Cho,Gyongyi Molnar Nadasdy,C. L. Weinstein,G. Steven Bova,William B. Isaacs,Paul Cairns,Homaira Nawroz,David Sidransky,Robert A. Casero,Paul S. Meltzer,Stephan A. Hahn,Scott E. Kern +14 more
TL;DR: The results indicate that whereas DPC4 inactivation is prevalent in pancreatic carcinoma (48%), it is distinctly uncommon in the other tumor types examined.
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Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
TL;DR: The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth and are frequently dysregulated in cancer and other hyperproliferative diseases.
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The natural polyamine spermine functions directly as a free radical scavenger
Hyo Chol Ha,Nilantha S. Sirisoma,Periannan Kuppusamy,Jay L. Zweier,Patrick M. Woster,Robert A. Casero +5 more
TL;DR: The polyamine spermine is shown here to function directly as a free radical scavenger, and adducts formed as a result of this function are identified, suggesting that s permine is a major natural intracellular compound capable of protecting DNA from free radical attack.
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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
Tino Schenk,Weihsu Claire Chen,Stefanie Göllner,Louise Howell,Liqing Jin,Katja Hebestreit,Hans-Ulrich Klein,Andreea C. Popescu,Alan Kenneth Burnett,Ken I. Mills,Robert A. Casero,Laurence J. Marton,Patrick M. Woster,Mark D. Minden,Martin Dugas,Jean C.Y. Wang,Jean C.Y. Wang,John E. Dick,John E. Dick,Carsten Müller-Tidow,Kevin Petrie,Arthur Zelent +21 more
TL;DR: Data identify LSD1 as a therapeutic target and strongly suggest that it may contribute to AML pathogenesis by inhibiting the normal pro-differentiative function of ATRA, paving the way for new combinatorial therapies for AML.
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Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands
Heather M. O'Hagan,Wei Wang,Subhojit Sen,Christina E. DeStefano Shields,Stella S. Lee,Yang W. Zhang,Eriko G. Clements,Yi Cai,Leander Van Neste,Hariharan Easwaran,Robert A. Casero,Robert A. Casero,Cynthia L. Sears,Stephen B. Baylin +13 more
TL;DR: It is demonstrated that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin, forming a silencing complex that may explain cancer-specific aberrant DNA methylation and transcriptional silencing.