C
Christine A. Iacobuzio-Donahue
Researcher at Johns Hopkins University
Publications - 162
Citations - 17820
Christine A. Iacobuzio-Donahue is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 72, co-authored 162 publications receiving 16555 citations. Previous affiliations of Christine A. Iacobuzio-Donahue include Memorial Sloan Kettering Cancer Center.
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Journal Article
Mesothelin Is Overexpressed in the Vast Majority of Ductal Adenocarcinomas of the Pancreas: Identification of a New Pancreatic Cancer Marker by Serial Analysis of Gene Expression (SAGE)
Pedram Argani,Christine A. Iacobuzio-Donahue,Byungwoo Ryu,Christophe Rosty,Michael Goggins,Robb E. Wilentz,Selva R. Murugesan,Steven D. Leach,Elizabeth M. Jaffee,Charles J. Yeo,John L. Cameron,Scott E. Kern,Ralph H. Hruban +12 more
TL;DR: Mesothelin is a new marker for pancreatic adenocarcinoma identified by gene expression analysis and has potential diagnostic, imaging, and therapeutic implications.
Journal ArticleDOI
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.
Christine A. Iacobuzio-Donahue,Anirban Maitra,Mari Olsen,Anson W. Lowe,N. Tjarda van Heek,Christophe Rosty,Kimberly Walter,Norihiro Sato,Antony R. Parker,Raheela Ashfaq,Elizabeth M. Jaffee,Byungwoo Ryu,Jessa Jones,James R. Eshleman,Charles J. Yeo,John L. Cameron,Scott E. Kern,Ralph H. Hruban,Patrick O. Brown,Michael Goggins +19 more
TL;DR: The genes and expressed sequence tags presented in this study provide clues to the pathobiology of pancreatic cancer and implicate a large number of potentially new molecular markers for the detection and treatment of Pancreatic cancer.
Journal Article
Highly Expressed Genes in Pancreatic Ductal Adenocarcinomas: A Comprehensive Characterization and Comparison of the Transcription Profiles Obtained from Three Major Technologies
Christine A. Iacobuzio-Donahue,Raheela Ashfaq,Anirban Maitra,N. Volkan Adsay,Grace L. C. Shen-Ong,Karin D. Berg,Michael A. Hollingsworth,John L. Cameron,Charles J. Yeo,Scott E. Kern,Michael Goggins,Ralph H. Hruban +11 more
TL;DR: A novel set of genes as highly expressed in pancreatic cancer is identified, the differential expression of previously reported genes are validated, and additional support is provided for those genes most differentially expressed to be translated into clinically useful targets.
Journal ArticleDOI
Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas.
N. Volkan Adsay,Kambiz Merati,Olca Basturk,Christine A. Iacobuzio-Donahue,Edi Levi,Jeanette D. Cheng,Fazlul H. Sarkar,Ralph H. Hruban,David S. Klimstra +8 more
TL;DR: IPNs include pathologically and biologically distinct epithelial patterns that support the existence of an intestinal pathway of carcinogenesis, and the presence of intestinal differentiation may potentially be used in prognostication and stratification of patients into appropriate treatment categories.
Journal ArticleDOI
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.
Christopher M. Heaphy,Andrea P. Subhawong,Seung-Mo Hong,Michael Goggins,Elizabeth A. Montgomery,Edward Gabrielson,George J. Netto,Jonathan I. Epstein,Tamara L. Lotan,William H. Westra,Ie Ming Shih,Christine A. Iacobuzio-Donahue,Anirban Maitra,Qing Kay Li,Charles G. Eberhart,Janis M. Taube,Dinesh Rakheja,Robert J. Kurman,Tzyy Choou Wu,Richard B.S. Roden,Pedram Argani,Angelo M. De Marzo,Luigi Terracciano,Michael Torbenson,Alan K. Meeker +24 more
TL;DR: The first report of ALT in carcinomas arising from the bladder, cervix, endometrium, esophagus, gallbladder, kidney, liver, and lung is reported, and ALT-positive cancers are predicted to be resistant to anti-telomerase therapies.