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Amy L. Bauer
Researcher at Los Alamos National Laboratory
Publications - 24
Citations - 1318
Amy L. Bauer is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Gene expression & Tyrosine hydroxylase. The author has an hindex of 15, co-authored 24 publications receiving 1215 citations. Previous affiliations of Amy L. Bauer include University of Michigan & University of Cincinnati Academic Health Center.
Papers
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A cell-based model exhibiting branching and anastomosis during tumor-induced angiogenesis.
TL;DR: This model provides a quantitative framework to test hypotheses on the biochemical and biomechanical mechanisms that control tumor-induced angiogenesis and shows inhomogeneities in the extravascular tissue lead to sprout branching and anastomosis, phenomena that emerge without any prescribed rules.
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Agent-based modeling of host-pathogen systems: The successes and challenges
TL;DR: Various agent-based models relevant to host–pathogen systems and their contributions to the authors' understanding of biological processes are reviewed and some limitations and challenges are pointed out.
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Topography of Extracellular Matrix Mediates Vascular Morphogenesis and Migration Speeds in Angiogenesis
TL;DR: This study validate the spatio-temporal mathematical model of angiogenesis against empirical data and explores matrix fiber alignment as a key factor contributing to peak sprout velocities and in mediating cell shape and orientation and quantifies the effects of proteolytic matrix degradation by the tip cell on sprout velocity.
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Calcium signaling stimulates translation of HIF-α during hypoxia
TL;DR: The data show that during general inhibition of protein synthesis by hypoxia, cap‐mediated translation of selected mRNAs is induced through the mTOR pathway, and it is proposed that calcium‐induced activation of cPKC‐αhypoxia partially protects an activity of mTOR from hypoxic inhibition.
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Regulation of tyrosine hydroxylase promoter activity by the von Hippel–Lindau tumor suppressor protein and hypoxia‐inducible transcription factors
Phillip O. Schnell,Monika L. Ignacak,Amy L. Bauer,Justin B. Striet,Waltke R. Paulding,Maria F. Czyzyk-Krzeska +5 more
TL;DR: In this article, the von Hippel-Lindau tumor suppressor protein (pVHL) was shown to play an important role in the regulation of tyrosine hydroxylase (TH) gene expression.