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Ana Carolina Da Silva
Researcher at Columbia University
Publications - 1
Citations - 223
Ana Carolina Da Silva is an academic researcher from Columbia University. The author has contributed to research in topics: AKT1 & Glucocorticoid receptor. The author has an hindex of 1, co-authored 1 publications receiving 188 citations.
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Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia
Erich Piovan,Erich Piovan,Jiyang Yu,Valeria Tosello,Daniel Herranz,Alberto Ambesi-Impiombato,Ana Carolina Da Silva,Marta Sanchez-Martin,Arianne Perez-Garcia,Isaura Rigo,Mireia Castillo,Stefano Indraccolo,Justin R. Cross,Elisa de Stanchina,Elisabeth Paietta,Elisabeth Paietta,Janis Racevskis,Janis Racevskis,Jacob M. Rowe,Martin S. Tallman,Giuseppe Basso,Jules P.P. Meijerink,Carlos Cordon-Cardo,Andrea Califano,Adolfo A. Ferrando +24 more
TL;DR: It is demonstrated that loss of PTEN and consequent AKT1 activation can effectively block glucocorticoid-induced apoptosis and induce resistance to glucoc Corticoid therapy, and pharmacologic inhibition of AKT with MK2206 effectively reverses glucocORTicoid resistance.