Ana Maria da Costa Ferreira

TL;DR: This is the first report unambiguously demonstrating the formation of the carbonate radical anion at physiological pHs by direct EPR spectroscopy, contributing to the understanding of nitrosoperoxocarboxylate decomposition pathways.

TL;DR: Investigations of 2-deoxy-d-ribose (DR) oxidation catalyzed by each of those complexes, using 2-thiobarbituric acid reactive species (TBARS) method, and detection of reactive oxygen species (ROS) formation by spin-trapping EPR, suggested that their mechanism of action in performing efficiently DNA cleavage occurs preferentially, but not only by oxidative pathways.

TL;DR: The binding of the new complexes to DNA, their capacity to cleave it, their cytotoxic activity, and uptake in tumoral cells are evaluated; they are among the most potent DNA cleavage agents reported so far.

TL;DR: Some copper(II) complexes with oxindole-derived ligands are discussed as potential antitumoral agents, in comparison to other complexes, based on the proposal of a synergistic effect on adding the metal coordinating and redox properties to the already demonstrated capability of these ligands to influence the angiogenesis and apoptosis processes.