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Ana P. Castano
Researcher at Harvard University
Publications - 42
Citations - 8523
Ana P. Castano is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & Photodynamic therapy. The author has an hindex of 22, co-authored 41 publications receiving 6904 citations. Previous affiliations of Ana P. Castano include Brigham and Women's Hospital.
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Photodynamic therapy and anti-tumour immunity
TL;DR: Photodynamic therapy uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system.
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Mechanisms in photodynamic therapy: part one—-photosensitizers, photochemistry and cellular localization
TL;DR: The most important factor governing the outcome of PDT is how the PS interacts with cells in the target tissue or tumor, and the key aspect of this interaction is the subcellular localization of the PS.
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Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death.
TL;DR: The mechanisms that operate in PDT on a cellular level are discussed, expected to lead to optimization of PDT as a tumor treatment, and to rational selection of combination therapies that include PDTAs a component.
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MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways
B. Nelson Chau,Cuiyan Xin,Jochen C. Hartner,Shuyu Ren,Ana P. Castano,Geoffrey Linn,Jian Li,Phong Tran,Vivek Kaimal,Xinqiang Huang,Aaron N. Chang,Shenyang Li,Aarti Kalra,Monica Grafals,Monica Grafals,Didier Portilla,Deidre Mackenna,Stuart H. Orkin,Jeremy S. Duffield +18 more
TL;DR: The finding that miR-21 is a major player in kidney fibrosis suggests that drugs that inhibit miR -21, like the complementary oligonucleotides used in this study, might prove to be useful therapies in humans.
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Mechanisms in photodynamic therapy: Part three—Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction
TL;DR: The anti-tumor effects of PDT are divided into three main mechanisms: Powerful anti-vascular effects can lead to thrombosis and hemorrhage in tumor blood vessels that subsequently lead to tumor death via deprivation of oxygen and nutrients.