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Anant B. Patel
Researcher at Centre for Cellular and Molecular Biology
Publications - 81
Citations - 3106
Anant B. Patel is an academic researcher from Centre for Cellular and Molecular Biology. The author has contributed to research in topics: Glutamate receptor & Glutamatergic. The author has an hindex of 26, co-authored 74 publications receiving 2634 citations. Previous affiliations of Anant B. Patel include Tata Institute of Fundamental Research & Academy of Scientific and Innovative Research.
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Journal ArticleDOI
Neuronal–Glial Glucose Oxidation and Glutamatergic–GABAergic Function
Fahmeed Hyder,Anant B. Patel,Albert Gjedde,Douglas L. Rothman,Kevin L. Behar,Robert G. Shulman +5 more
TL;DR: The revised model shows that glia produce at least 8% oftotal oxidative ATP and GABAergic neurons generate ~18% of total oxidative ATP in neurons, and takes up ~26% of the total glucose oxidized, but ~30% less than predicted by the prior model.
Journal ArticleDOI
The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo
Anant B. Patel,Robin A. de Graaf,Graeme F. Mason,Douglas L. Rothman,Robert G. Shulman,Kevin L. Behar +5 more
TL;DR: In isoelectric cortex, glucose oxidation was reduced >3-fold in glutamatergic and GABAergic neurons, and neurotransmitter cycling was below detection, Hence, in both cell types, the primary energetic costs are associated with neurotransmission, which increase together as cortical activity is increased.
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Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle
Anant B. Patel,James C. K. Lai,Golam M. I. Chowdhury,Fahmeed Hyder,Douglas L. Rothman,Robert G. Shulman,Kevin L. Behar +6 more
TL;DR: It is suggested that neuronal glucose-derived pyruvate is the major oxidative fuel for activated neurons, not lactate-derived from astrocytes, contradicting predictions of the original astroCyte-to-neuron lactate shuttle model under the range of study conditions.
Journal ArticleDOI
Glutamatergic Neurotransmission and Neuronal Glucose Oxidation are Coupled during Intense Neuronal Activation
Anant B. Patel,Robin A. de Graaf,Graeme F. Mason,Tomoyuki Kanamatsu,Douglas L. Rothman,Robert G. Shulman,Kevin L. Behar +6 more
TL;DR: Results indicate that neuronal glucose oxidation and not total glucose utilization is coupled to the glutamate/glutamine cycle during intense cortical activation.
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In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism.
TL;DR: 1H‐[13C]‐NMR spectroscopy can now be used to discriminate glutamatergic and GABAergic neuronal activity and allows the detection of energy metabolism and neurotransmission during functional activation, thereby further strengthening the understanding of the neurochemical basis of brain function.