James C. K. Lai

TL;DR: Further studies are needed to define the cause of epileptic seizures in mesial temporal lobe epilepsy, but the loss of glutamine synthetase may provide a new focus for therapeutic interventions in MTLE.

TL;DR: It is found that TiO2 micro- and nanoparticles induced cell death on both human cell types in a concentration-related manner and it was noted that zinc oxide (ZnO) nanoparticles were the most effective,TiO2 nanoparticles the secondmost effective, and magnesium oxide (MgO), the least effective in inducing cell death in U87 cells.

TL;DR: It is suggested that neuronal glucose-derived pyruvate is the major oxidative fuel for activated neurons, not lactate-derived from astrocytes, contradicting predictions of the original astroCyte-to-neuron lactate shuttle model under the range of study conditions.

TL;DR: The hypothesis that a deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, is supported and restoration of glutamine Synthetase may represent a novel approach to therapeutic intervention in this disease.

TL;DR: It is emphasized that some of the conclusions about neuronal-astrocytic interactions reached on the basis of studies in cultured cells and confirmed in intact tissue may not yet have been completely integrated into general neuroscience knowledge.