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Anatoly I. Miroshnikov
Researcher at Russian Academy of Sciences
Publications - 118
Citations - 1361
Anatoly I. Miroshnikov is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Nucleoside & Purine nucleoside phosphorylase. The author has an hindex of 19, co-authored 107 publications receiving 1235 citations. Previous affiliations of Anatoly I. Miroshnikov include Moscow State University.
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Journal ArticleDOI
Recognition of Artificial Nucleobases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant in the Synthesis of Base-Modified Nucleosides.
Ilja V. Fateev,Maria I. Kharitonova,Konstantin V. Antonov,Irina D. Konstantinova,Vasily N. Stepanenko,Roman S. Esipov,Frank Seela,Kartik Temburnikar,Katherine L. Seley-Radtke,Vladimir A. Stepchenko,Yuri A. Sokolov,Anatoly I. Miroshnikov,Igor A. Mikhailopulo +12 more
TL;DR: It was found that the Ser90 residue of the PNP plays an important role in the binding and activation of 8-aza-7-deazapurines in the synthesis of their nucleosides and in the dephosphorylation of intermediary formed 2- deoxy-α-D-ribofuranose-1-phosphate in the trans-2-deoxyribosylation reaction.
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Improved synthesis of trinucleotide phosphoramidites and generation of randomized oligonucleotide libraries.
Andrey Yagodkin,Alex Azhayev,Jarkko Roivainen,Maxim Antopolsky,Alexei L. Kayushin,Maria Korosteleva,Anatoly I. Miroshnikov,John B. Randolph,Hugh Mackie +8 more
TL;DR: A new method to produce a set of 20 high quality trinucleotide phosphoramidites on a 5–10 g scale each was developed and mutagenic oligonucleotides are synthesized employing mixtures of building blocks 7 as well as following the new synthetic protocol.
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Isosteric ribavirin analogues: Synthesis and antiviral activities.
Nikolay Zhurilo,Mikhail V. Chudinov,Andrey V. Matveev,Olga S. Smirnova,Irina D. Konstantinova,Anatoly I. Miroshnikov,Alexander N. Prutkov,Lyubov E. Grebenkina,Natalya V. Pulkova,Vitaly I. Shvets +9 more
TL;DR: The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism and show significant antiviral action against hepatitis C virus, herpes simplex and influenza A virus comparable to that of Ribavirin itself.
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Chemical polysialylation: design of conjugated human oxyntomodulin with a prolonged anorexic effect in vivo.
Ivan I. Vorobiev,Viktor Matskevich,S. V. Kovnir,Nadezhda A. Orlova,V. D. Knorre,Sanjay Jain,Dmitry Genkin,A. G. Gabibov,Anatoly I. Miroshnikov +8 more
TL;DR: The conjugate obtained was resistant to the DPP-IV protease and may be used to create OXM derivatives and other related hormones to obtain long-lasting variants, with improved suitability for clinical use.
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An Enzymatic Transglycosylation of Purine Bases
Jarkko Roivainen,Tatiana G. Elizarova,Seppo Lapinjoki,Igor A. Mikhailopulo,Roman S. Esipov,Anatoly I. Miroshnikov +5 more
TL;DR: The glycosylation of N6-benzoyladenine and N2-acetylguanine and its O6-derivatives is not accompanied by deacylation of bases and an efficient enzymatic method is suggested for the synthesis of purine nucleosides containing diverse substituents at the C6 and C2 carbon atoms.