K
Kartik Temburnikar
Researcher at University of Maryland, Baltimore County
Publications - 12
Citations - 234
Kartik Temburnikar is an academic researcher from University of Maryland, Baltimore County. The author has contributed to research in topics: Cell cycle checkpoint & Prodrug. The author has an hindex of 8, co-authored 11 publications receiving 194 citations. Previous affiliations of Kartik Temburnikar include Arizona State University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Evaluating TNA stability under simulated physiological conditions
Michelle C. Culbertson,Kartik Temburnikar,Sujay P. Sau,Jen-Yu Liao,Saikat Bala,John C. Chaput,John C. Chaput +6 more
TL;DR: It is shown that TNA remains undigested after 7days of incubation in the presence of either 50% human serum or human liver microsomes and is stable against snake venom phosphordiesterase and protected from nuclease digestion and complementary RNA strands from RNA degrading enzymes.
Journal ArticleDOI
Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides.
TL;DR: Recent reports on the modular synthesis of C-nucleosides with a focus on D-ribonolactone and sugar modifications that have resulted in potent lead molecules are described.
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1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents.
Mikhail S. Novikov,Olga N. Ivanova,Alexander V. Ivanov,Alexander Ozerov,Vladimir T. Valuev-Elliston,Kartik Temburnikar,G. V. Gurskaya,Sergey N. Kochetkov,Christophe Pannecouque,Jan Balzarini,Katherine L. Seley-Radtke +10 more
TL;DR: Evaluation revealed that the inhibitors were active against most nevirapine-resistant mono- and di-substituted RTs with the exception of the V106A RT, and can be regarded as potential lead compounds against the wild-type virus and drug-resistant forms.
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Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines
Kartik Temburnikar,Sarah C. Zimmermann,Nathaniel T. Kim,Christina R. Ross,Christopher B. Gelbmann,Christine E. Salomon,Gerald M. Wilson,Jan Balzarini,Katherine L. Seley-Radtke +8 more
TL;DR: The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines and the necessity of the chlorine at the C4-position for biological activity was indicated.
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Recognition of Artificial Nucleobases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant in the Synthesis of Base-Modified Nucleosides.
Ilja V. Fateev,Maria I. Kharitonova,Konstantin V. Antonov,Irina D. Konstantinova,Vasily N. Stepanenko,Roman S. Esipov,Frank Seela,Kartik Temburnikar,Katherine L. Seley-Radtke,Vladimir A. Stepchenko,Yuri A. Sokolov,Anatoly I. Miroshnikov,Igor A. Mikhailopulo +12 more
TL;DR: It was found that the Ser90 residue of the PNP plays an important role in the binding and activation of 8-aza-7-deazapurines in the synthesis of their nucleosides and in the dephosphorylation of intermediary formed 2- deoxy-α-D-ribofuranose-1-phosphate in the trans-2-deoxyribosylation reaction.