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Anders Brunmark
Researcher at Scripps Research Institute
Publications - 33
Citations - 3911
Anders Brunmark is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: T-cell receptor & Major histocompatibility complex. The author has an hindex of 23, co-authored 33 publications receiving 3833 citations. Previous affiliations of Anders Brunmark include Johnson & Johnson Pharmaceutical Research and Development & Johnson & Johnson.
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Journal ArticleDOI
An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex
K. Christopher Garcia,Massimo Degano,Robyn L. Stanfield,Anders Brunmark,Michael R. Jackson,Per A. Peterson,Luc Teyton,Ian A. Wilson +7 more
TL;DR: In this article, the x-ray structure of the complete extracellular fragment of a glycosylated αβ T cell receptor (TCR) was determined at 2.5 angstroms, and its orientation bound to a class I MHC-peptide (pMHC) complex was elucidated from crystals of the TCR- pMHC complex.
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Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues.
Michael R. D'Andrea,Claudia K. Derian,Didier Leturcq,Sherry M. Baker,Anders Brunmark,Ping Ling,Andrew L. Darrow,Rosemary J. Santulli,Lawrence F. Brass,Patricia Andrade Gordon +9 more
TL;DR: Tissue-specific cellular localization of PAR-2 in normal human tissues by immunohistochemical techniques is provided and a role for PAR-1 in the skin was further supported by its immunolocalization in the epidermis and strong immunolabeling was observed throughout the gastrointestinal tract.
Journal ArticleDOI
Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes.
Yuri Sykulev,Anders Brunmark,Michael R. Jackson,Richard J. Cohen,Per A. Peterson,Herman N. Eisen +5 more
TL;DR: The net rate of accumulation of complexes formed by the antigen-specific receptor of T cells (TCR) of a T cell clone with its natural ligand, an octapeptide in association with Ld, approaches the maximal value determined by the affinity of the TCR for this peptide-MHC ligand in 1-2 min, which is well within the lifetime of transient T cell-target cell conjugates.
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T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells.
Inkyu Hwang,Jing-Feng Huang,Hidehiro Kishimoto,Anders Brunmark,Per A. Peterson,Michael R. Jackson,Charles D. Surh,Zeling Cai,Jonathan Sprent +8 more
TL;DR: It is shown that during T cell–APC interaction, T cells rapidly absorb various molecules from APCs onto the cell membrane and then internalize these molecules.
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High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins
Yuri Sykulev,Anders Brunmark,Theodore J. Tsomides,Shigeki Kageyama,Mike Jackson,Per A. Peterson,Herman N. Eisen +6 more
TL;DR: It is proposed that TCR affinities are generally likely to be higher for allogeneic M HC-peptide complexes than for syngeneic MHC-pePTide complexes.