M
Michael R. Jackson
Researcher at Scripps Research Institute
Publications - 87
Citations - 8380
Michael R. Jackson is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Cytotoxic T cell & Major histocompatibility complex. The author has an hindex of 39, co-authored 87 publications receiving 8223 citations. Previous affiliations of Michael R. Jackson include Johnson & Johnson & Anschutz Medical Campus.
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Journal ArticleDOI
An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex
K. Christopher Garcia,Massimo Degano,Robyn L. Stanfield,Anders Brunmark,Michael R. Jackson,Per A. Peterson,Luc Teyton,Ian A. Wilson +7 more
TL;DR: In this article, the x-ray structure of the complete extracellular fragment of a glycosylated αβ T cell receptor (TCR) was determined at 2.5 angstroms, and its orientation bound to a class I MHC-peptide (pMHC) complex was elucidated from crystals of the TCR- pMHC complex.
Journal ArticleDOI
Cloning and functional expression of the human histamine H3 receptor.
Timothy W. Lovenberg,Barbara Roland,Sandy J. Wilson,Xiaoxia Jiang,Jayashree Pyati,Arne Huvar,Michael R. Jackson,Mark G. Erlander +7 more
TL;DR: A directed effort to discover novel G protein-coupled receptors through homology searching of expressed sequence tag databases identified a partial clone (GPCR97) that had significant homology to biogenic amine receptors.
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Gene expression profiles of laser-captured adjacent neuronal subtypes.
Lin Luo,Ranelle C. Salunga,Hongqing Guo,Anton Bittner,K.C. Joy,Jose E. Galindo,Huinian Xiao,Kathryn E. Rogers,Jackson S. Wan,Michael R. Jackson,Mark G. Erlander +10 more
TL;DR: Ian Tomlinson and Walter Bodmer point out that an increased mutation rate does not necessarily cause a tumor to grow and that selection is in fact the mechanism that drives the cellular, somatic evolution that leads to cancer.
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TCR-mediated internalization of peptide-MHC complexes acquired by T cells
Jing-Feng Huang,Young Yang,Homero Sepulveda,Weixing Shi,Inkyu Hwang,Per A. Peterson,Michael R. Jackson,Jonathan Sprent,Zeling Cai +8 more
TL;DR: This form of immunoregulation could explain the "exhaustion" of T cell responses that is induced by high viral loads and may serve to down-regulate immune responses.
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The Molecular Chaperone Calnexin Binds Glc1Man9GlcNAc2 Oligosaccharide as an Initial Step in Recognizing Unfolded Glycoproteins
Felecia E. Ware,Aikaterini Vassilakos,Per A. Peterson,Michael R. Jackson,Mark A. Lehrman,David B. Williams +5 more
TL;DR: Findings suggest that once complexes between calnexin and glycoproteins are formed, oligosaccharide binding does not contribute significantly to the overall interaction, however, it is likely that the binding of Glc1Man9GlcNAc2 oligosACcharides is a crucial event during the initial recognition of newly synthesized glycoprotein by cal Nexin.