Andras Kapus

TL;DR: The results uncover an important aspect of the cross-talk between TGF β and Hippo signaling, showing that TGFβ induces TAZ via a Smad3-independent, p38- and MRTF-mediated and yet MRTF translocation-independent mechanism.

TL;DR: Members of the Na+/H+ exchanger (NHE) family mediate electroneutral countertransport of H+ for Na+ across cellular membranes and mediate transepithelial Na+ transport processes and housekeeping functions such as the regulation of cellular and organellar pH and volume.

TL;DR: Hypertonicity modulates endothelial ICAM-1 expression as one possible protective mechanism against I/R injury and minimizes PMN-mediated injury.

TL;DR: These studies show that oxidant stress is able to augment macrophage responsiveness to LPS as evidenced by earlier and increased NF-κB translocation, and provide a novel potential mechanism whereby oxidants might prime alveolar macrophages for altered responsiveness to subsequent inflammatory stimuli and suggest different cellular targets for immunomodulation following ischemia/reperfusion.

TL;DR: HTS resuscitation exerts an immunomodulatory effect on alveolar macrophages by shifting the balance of pro- and counter-inflammatory cytokine production in favor of an anti-inflammatory response.