A
Andrea Casagrande
Researcher at Istituto Superiore di Sanità
Publications - 15
Citations - 1297
Andrea Casagrande is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Aspergillosis & Inflammation. The author has an hindex of 14, co-authored 15 publications receiving 1189 citations. Previous affiliations of Andrea Casagrande include University of Perugia.
Papers
More filters
Journal ArticleDOI
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
Antonella De Luca,Sanne P. Smeekens,Andrea Casagrande,Rossana G. Iannitti,Kara L. Conway,Mark S. Gresnigt,Jakob Begun,Theo S. Plantinga,Leo A. B. Joosten,Jos W. M. van der Meer,Georgios Chamilos,Mihai G. Netea,Ramnik J. Xavier,Ramnik J. Xavier,Charles A. Dinarello,Charles A. Dinarello,Luigina Romani,Frank L. van de Veerdonk,Frank L. van de Veerdonk +18 more
TL;DR: Inflammation in CGD is due to IL-1–dependent mechanisms, such as decreased autophagy and increased inflammasome activation, which are linked pathological conditions inCGD that can be restored byIL-1 receptor blockade.
Journal ArticleDOI
No metagenomic evidence of tumorigenic viruses in cancers from a selected cohort of immunosuppressed subjects.
Nunzia Passaro,Andrea Casagrande,Matteo Chiara,Bruno Fosso,Caterina Manzari,Anna Maria D'Erchia,Anna Maria D'Erchia,Samuele Iesari,Francesco Pisani,Antonio Famulari,Patrizia Tulissi,Stefania Mastrosimone,Maria Cristina Maresca,Giuseppe Mercante,Giuseppe Spriano,Giacomo Corrado,Enrico Vizza,Anna Rosa Garbuglia,Maria Rosaria Capobianchi,Carla Mottini,Alessandra Cenci,Marco Tartaglia,Alessandro Nanni Costa,Graziano Pesole,Graziano Pesole,Marco Crescenzi +25 more
TL;DR: While a variegated bacterial microbiome was associated with each tumor, no evidence of the presence of putative oncoviruses was found and suggest that new human tumorigenic viruses are not common even in immunosuppressed populations.
Journal ArticleDOI
IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis
Silvia Moretti,Silvia Bozza,Vasilis Oikonomou,Giorgia Renga,Andrea Casagrande,Rossana G. Iannitti,Matteo Puccetti,Cecilia Garlanda,Soo-Hyun Kim,Suzhao Li,Frank L. van de Veerdonk,Charles A. Dinarello,Luigina Romani +12 more
TL;DR: By preventing activation of the NLRP3 inflammasome and reducing IL-1β secretion, IL-37 functions as a broad spectrum inhibitor of the innate response to infection-mediated inflammation, and could be considered to be therapeutic in reducing the pulmonary damage due to non-resolving Aspergillus infection and disease.
Journal ArticleDOI
Impaired Antifungal Effector Activity but Not Inflammatory Cell Recruitment in Interleukin-6-Deficient Mice with Invasive Pulmonary Aspergillosis
Elio Cenci,Antonella Mencacci,Andrea Casagrande,Paolo Mosci,Francesco Bistoni,Luigina Romani +5 more
TL;DR: The results indicate that IL-6(-/-) mice were more susceptible than wild-type mice to IPA and was associated with increased inflammatory pathology, decreased antifungal effector functions of phagocytes, and impaired development of protective type 1 responses.
Journal ArticleDOI
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis
Agostinho Carvalho,Gloria Giovannini,Antonella De Luca,Carmen D'Angelo,Andrea Casagrande,Rossana G. Iannitti,Giovanni Ricci,Cristina Cunha,Luigina Romani +8 more
TL;DR: The net activity of dectin-1 in antifungal mucosal immunity is dependent on the host's genetic background, which affects both the innate cytokine production and the adaptive Th1/Th17 cell activation upon dectIn-1 signaling.