A
Andrea Corsinotti
Researcher at University of Edinburgh
Publications - 5
Citations - 264
Andrea Corsinotti is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Embryonic stem cell & SOX2. The author has an hindex of 4, co-authored 5 publications receiving 187 citations. Previous affiliations of Andrea Corsinotti include University of Tsukuba.
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Journal ArticleDOI
TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer
Anna C. Groner,Laura Cato,Jonas de Tribolet-Hardy,Tiziano Bernasocchi,Hana Janouskova,Diana Melchers,René Houtman,Andrew C.B. Cato,Patrick Tschopp,Lei Gu,Andrea Corsinotti,Andrea Corsinotti,Qing Zhong,Christian D. Fankhauser,Christine Fritz,Cédric Poyet,Ulrich Wagner,Tiannan Guo,Ruedi Aebersold,Ruedi Aebersold,Levi A. Garraway,Levi A. Garraway,Peter J. Wild,Jean-Philippe Theurillat,Jean-Philippe Theurillat,Myles Brown +25 more
TL;DR: It is shown that recurrent PC-driver mutations in speckle-type POZ protein (SPOP) stabilize the TRIM24 protein, which promotes proliferation under low androgen conditions, and provides a rationale for therapeutic TRIM 24 targeting in SPOP mutant and CRPC patients.
Journal ArticleDOI
Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation
Nicola Festuccia,Florian Halbritter,Andrea Corsinotti,Andrea Corsinotti,Alessia Gagliardi,Douglas Colby,Simon R. Tomlinson,Ian Chambers +7 more
TL;DR: Mechanistic differences in TF function act cumulatively to restrict potency during exit from naïve pluripotency.
Journal ArticleDOI
Distinct SoxB1 networks are required for naïve and primed pluripotency.
Andrea Corsinotti,Andrea Corsinotti,Frederick C. K. Wong,Tülin Tatar,Iwona Szczerbinska,Florian Halbritter,Douglas Colby,Sabine Gogolok,Raphaël Pantier,Kirsten Liggat,Elham S Mirfazeli,Elisa Hall-Ponsele,Nicholas P. Mullin,Valerie Wilson,Ian Chambers +14 more
TL;DR: It is shown that Sox2 can be deleted from epiblast stem cell (EpiSC) pluripotency with impunity, due to a shift in the balance of SoxB1 expression in EpiSCs, which have decreased Sox2 and increased Sox3 compared to ESCs.
Peer ReviewDOI
Author response: Distinct SoxB1 networks are required for naïve and primed pluripotency
Andrea Corsinotti,Andrea Corsinotti,Frederick C. K. Wong,Tülin Tatar,Iwona Szczerbinska,Florian Halbritter,Douglas Colby,Sabine Gogolok,Raphaël Pantier,Kirsten Liggat,Elham S Mirfazeli,Elisa Hall-Ponsele,Nicholas P. Mullin,Valerie Wilson,Ian Chambers +14 more
Posted ContentDOI
Distinct SoxB1 networks are required for naïve and primed pluripotency
Andrea Corsinotti,Frederick C. K. Wong,Tülin Tatar,Iwona Szczerbinska,Florian Halbritter,Douglas Colby,Sabine Gogolok,Raphaël Pantier,Kirsten Liggat,Elham S Mirfazeli,Elisa Hall-Ponsele,Nicholas P. Mullin,Valerie Wilson,Ian Chambers +13 more
TL;DR: It is shown that Sox2 can be deleted from epiblast stem cell (EpiSC) pluripotency with impunity, due to a shift in the balance of SoxB1 expression in EpiSCs, which have decreased Sox2 and increased Sox3 compared to ESCs.