Peter J. Wild

TL;DR: SPOP mutations may define a new molecular subtype of prostate cancer, with mutations involving the SPOP substrate-binding cleft in 6–15% of tumors across multiple independent cohorts.

TL;DR: The coupled immunohistochemical and immunocytochemical methods with high-resolution laser ablation to CyTOF mass cytometry enables the simultaneous imaging of 32 proteins and protein modifications at subcellular resolution and complements existing imaging approaches.

TL;DR: Analysis of RNA expression levels of 40 genes of the Wnt pathway by chip hybridization of microdissected matched pairs of primary prostate carcinomas revealed strong cytoplasmic perinuclear WIF1 expression in normal epithelial cells of the prostate, breast, lung, and urinary bladder, indicating that loss of Wif1 expression may be an early event in tumourigenesis in these tissues.

TL;DR: In the absence of helper virus, the vectors efficiently infected rat neural cells in culture or in the brain with minimal cytopathic effects and vector DNA persisted for this period, facilitating studies on neuronal physiology and potential therapeutic applications.

TL;DR: Findings indicate a major role of monocyte/macrophage dysfunction in the pathophysiology of GvHD and strongly suggest a future risk assessment or even donor selection through NOD2/CARD15 typing.