A
Anna C. Groner
Researcher at Harvard University
Publications - 20
Citations - 2891
Anna C. Groner is an academic researcher from Harvard University. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 17, co-authored 20 publications receiving 2425 citations. Previous affiliations of Anna C. Groner include ETH Zurich & École Polytechnique Fédérale de Lausanne.
Papers
More filters
Journal ArticleDOI
EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
Kexin Xu,Zhenhua Jeremy Wu,Anna C. Groner,Housheng Hansen He,Changmeng Cai,Rosina T. Lis,Rosina T. Lis,Xiaoqiu Wu,Edward C. Stack,Edward C. Stack,Massimo Loda,Tao Liu,Han Xu,Laura Cato,James E. Thornton,James E. Thornton,Richard I. Gregory,Richard I. Gregory,Colm Morrissey,Robert L. Vessella,Rodolfo Montironi,Cristina Magi-Galluzzi,Philip W. Kantoff,Steven P. Balk,X. Shirley Liu,Myles Brown +25 more
TL;DR: It is found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independent of its role as a transcriptional repressor, and involves the ability of EzH2 to act as a coactivator for critical transcription factors including the androgen receptor.
Journal ArticleDOI
Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa
Volker Busskamp,Jens Duebel,D. Balya,Mathias Fradot,Mathias Fradot,Mathias Fradot,Tim J. Viney,Sandra Siegert,Anna C. Groner,Erik Cabuy,Valérie Forster,Valérie Forster,Valérie Forster,Mathias W. Seeliger,Martin Biel,Peter Humphries,Michel Paques,Saddek Mohand-Said,Didier Trono,Karl Deisseroth,José-Alain Sahel,Serge Picaud,Botond Roska +22 more
TL;DR: It is shown that expression of archaebacterial halorhodopsin in light-insensitive cones can substitute for the native phototransduction cascade and restore light sensitivity in mouse models of retinitis pigmentosa.
Journal ArticleDOI
KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading
Anna C. Groner,Sylvain Meylan,Angela Ciuffi,Nadine Zangger,Giovanna Ambrosini,Giovanna Ambrosini,Nicolas Dénervaud,Philipp Bucher,Philipp Bucher,Didier Trono +9 more
TL;DR: It is demonstrated that KRAB and its corepressor KAP1 can silence promoters located several tens of kilobases away from their DNA binding sites, with an efficiency which is generally higher for promoters located within 15 kb or less.
Journal ArticleDOI
TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer
Anna C. Groner,Laura Cato,Jonas de Tribolet-Hardy,Tiziano Bernasocchi,Hana Janouskova,Diana Melchers,René Houtman,Andrew C.B. Cato,Patrick Tschopp,Lei Gu,Andrea Corsinotti,Andrea Corsinotti,Qing Zhong,Christian D. Fankhauser,Christine Fritz,Cédric Poyet,Ulrich Wagner,Tiannan Guo,Ruedi Aebersold,Ruedi Aebersold,Levi A. Garraway,Levi A. Garraway,Peter J. Wild,Jean-Philippe Theurillat,Jean-Philippe Theurillat,Myles Brown +25 more
TL;DR: It is shown that recurrent PC-driver mutations in speckle-type POZ protein (SPOP) stabilize the TRIM24 protein, which promotes proliferation under low androgen conditions, and provides a rationale for therapeutic TRIM 24 targeting in SPOP mutant and CRPC patients.
Journal ArticleDOI
Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression.
Cristina Márquez,Guillaume L. Poirier,Maria Isabel Cordero,Marianne Hald Larsen,Anna C. Groner,Julien Marquis,Pierre J. Magistretti,Didier Trono,Carmen Sandi +8 more
TL;DR: Novel data is presented highlighting changes in the serotonergic system in the prefrontal cortex—and pointing at epigenetic control of the MAOA gene—in the establishment of the link between peripubertal stress and later pathological aggression.