Andrea J. Moore

TL;DR: In this article, the expression of proteases and collagen involved in early vein wall remodeling was investigated in early venous thrombosis in the mouse, and the results showed that wound healing after DVT is similar to wound healing and is associated with increased procollagen gene expression and total collagen.

TL;DR: It is concluded that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-γ.

TL;DR: Data suggest both a static component and the thrombus directs vein wall injury via multiple mechanisms, and limited stasis, non-stasis thrombosis and non-thrombotic IVC occlusion showed a lesser inflammatory response.

TL;DR: A critical early role for PMN is suggested in post DVT vein wall remodeling and thrombus neovascularization and vein wall injury after DVT, which is associated with neutrophil (PMN) influx.

TL;DR: Compared with nontreated PE, LMWH is the only therapy associated with a significant reduction in late intimal hyperplasia and, with the exception of TGF-beta, lower profibrotic growth-factor production.