E
Erin Lynch
Researcher at University of Michigan
Publications - 11
Citations - 524
Erin Lynch is an academic researcher from University of Michigan. The author has contributed to research in topics: Inferior vena cava & Vein. The author has an hindex of 9, co-authored 11 publications receiving 488 citations.
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Journal ArticleDOI
Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse model
Kristopher B. Deatrick,Jonathan L. Eliason,Erin Lynch,Andrea J. Moore,Nicholas A. Dewyer,Manu R. Varma,Charles G. Pearce,Gilbert R. Upchurch,Thomas W. Wakefield,Peter K. Henke +9 more
TL;DR: In this article, the expression of proteases and collagen involved in early vein wall remodeling was investigated in early venous thrombosis in the mouse, and the results showed that wound healing after DVT is similar to wound healing and is associated with increased procollagen gene expression and total collagen.
Journal ArticleDOI
Targeted Deletion of CCR2 Impairs Deep Vein Thombosis Resolution in a Mouse Model
Peter K. Henke,Charles G. Pearce,Daria M. Moaveni,Andrea J. Moore,Erin Lynch,Christopher Longo,Manu R. Varma,Nicholas A. Dewyer,K. Barry Deatrick,Gilbert R. Upchurch,Thomas W. Wakefield,Cory M. Hogaboam,Steven L. Kunkel +12 more
TL;DR: It is concluded that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-γ.
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Early Increased MT1-MMP Expression and Late MMP-2 and MMP-9 Activity during Angiotensin II Induced Aneurysm Formation
Matthew J. Eagleton,Nicole E. Ballard,Erin Lynch,Sunita D. Srivastava,Gilbert R. Upchurch,James C. Stanley +5 more
TL;DR: Angiotensin II induces an early increase in aortic MT1-MMP expression with a subsequent increase in M MP-2 and MMP-9 activity and the process by which these changes cause aneurysm formation warrants further investigation.
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Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesis.
Peter K. Henke,Manu R. Varma,Daria K. Moaveni,Nicholas A. Dewyer,Andrea J. Moore,Erin Lynch,Christopher Longo,C. Barry Deatrick,Steven L. Kunkel,Gilbert R. Upchurch,Thomas W. Wakefield +10 more
TL;DR: Data suggest both a static component and the thrombus directs vein wall injury via multiple mechanisms, and limited stasis, non-stasis thrombosis and non-thrombotic IVC occlusion showed a lesser inflammatory response.
Journal ArticleDOI
Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization
Peter K. Henke,Manu R. Varma,K. Barry Deatrick,Nicholas A. Dewyer,Erin Lynch,Andrea J. Moore,Derek A. Dubay,Pasu Sukheepod,Charles G. Pearce,Gilbert R. Upchurch,Steven L. Kunkel,Michael G. Franz,Thomas W +12 more
TL;DR: A critical early role for PMN is suggested in post DVT vein wall remodeling and thrombus neovascularization and vein wall injury after DVT, which is associated with neutrophil (PMN) influx.