C
Charles G. Pearce
Researcher at University of Michigan
Publications - 9
Citations - 481
Charles G. Pearce is an academic researcher from University of Michigan. The author has contributed to research in topics: Vein & Venous thrombosis. The author has an hindex of 7, co-authored 9 publications receiving 446 citations.
Papers
More filters
Journal ArticleDOI
Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse model
Kristopher B. Deatrick,Jonathan L. Eliason,Erin Lynch,Andrea J. Moore,Nicholas A. Dewyer,Manu R. Varma,Charles G. Pearce,Gilbert R. Upchurch,Thomas W. Wakefield,Peter K. Henke +9 more
TL;DR: In this article, the expression of proteases and collagen involved in early vein wall remodeling was investigated in early venous thrombosis in the mouse, and the results showed that wound healing after DVT is similar to wound healing and is associated with increased procollagen gene expression and total collagen.
Journal ArticleDOI
Targeted Deletion of CCR2 Impairs Deep Vein Thombosis Resolution in a Mouse Model
Peter K. Henke,Charles G. Pearce,Daria M. Moaveni,Andrea J. Moore,Erin Lynch,Christopher Longo,Manu R. Varma,Nicholas A. Dewyer,K. Barry Deatrick,Gilbert R. Upchurch,Thomas W. Wakefield,Cory M. Hogaboam,Steven L. Kunkel +12 more
TL;DR: It is concluded that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-γ.
Journal ArticleDOI
L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation.
Kevin K. Hannawa,Jonathan L. Eliason,Derek T. Woodrum,Charles G. Pearce,Karen J. Roelofs,Vladimir Grigoryants,Matthew J. Eagleton,Peter K. Henke,Thomas W. Wakefield,Daniel D. Myers,James C. Stanley,Gilbert R. Upchurch +11 more
TL;DR: L-selectin–mediated neutrophil recruitment may be a critical early step in AAA formation in rodents.
Journal ArticleDOI
Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms.
Vladimir Grigoryants,Kevin K. Hannawa,Charles G. Pearce,Indranil Sinha,Karen J. Roelofs,Gorav Ailawadi,Kristopher B. Deatrick,Derek T. Woodrum,Brenda S. Cho,Peter K. Henke,James C. Stanley,Matthew J. Eagleton,Gilbert R. Upchurch +12 more
TL;DR: The selective estrogen receptor modulator tamoxifen inhibits the development of AAAs in male rats in association with an up-regulation of catalase and inhibition of aortic wall neutrophil infiltration.
Journal ArticleDOI
Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization
Peter K. Henke,Manu R. Varma,K. Barry Deatrick,Nicholas A. Dewyer,Erin Lynch,Andrea J. Moore,Derek A. Dubay,Pasu Sukheepod,Charles G. Pearce,Gilbert R. Upchurch,Steven L. Kunkel,Michael G. Franz,Thomas W +12 more
TL;DR: A critical early role for PMN is suggested in post DVT vein wall remodeling and thrombus neovascularization and vein wall injury after DVT, which is associated with neutrophil (PMN) influx.