Andrea S. Les

TL;DR: It is hypothesized that exercise may slow AAA growth by decreasing inflammatory burden, peripheral resistance, and adverse hemodynamic conditions such as low, oscillatory shear stress and the increased MWSS, decreased OSI, and moderate turbulence present during exercise may attenuate AAA growth.

TL;DR: This work describes noninvasive methods to quantify and determine a scaling law for wall shear stress (WSS), and provides the opportunity to serially quantify changes in WSS during disease progression and/or therapeutic intervention.

TL;DR: The 11C-PiB-PET imaging results demonstrated reduction of fibrillar Aβ accumulation in patients with Alzheimer disease treated with bapineuzumab; however, as no clinical benefit was observed, the findings are consistent with the hypotheses that bapinesumab may not have been initiated early enough in the disease course, the doses were insufficient, or the most critical Aβ species were inadequately targeted.

TL;DR: The capabilities of numerical simulations incorporating deformable walls to capture both the vessel wall motion and wave propagation by accurately predicting the changes in the flow and pressure waveforms at various locations down the length of the deformable flow phantoms are demonstrated.

TL;DR: It is postulate that augmentation of mean infrarenal flow during exercise may reduce chronic flow stasis that may influence mural thrombus burden, degradation of the vessel wall, and aneurysm growth.