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Andrea Soza
Researcher at San Sebastián University
Publications - 46
Citations - 1956
Andrea Soza is an academic researcher from San Sebastián University. The author has contributed to research in topics: Proteasome & MHC class I. The author has an hindex of 20, co-authored 44 publications receiving 1749 citations. Previous affiliations of Andrea Soza include Tel Aviv University & Pontifical Catholic University of Chile.
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Journal ArticleDOI
A role for the proteasome regulator PA28α in antigen presentation
Marcus Groettrup,Andrea Soza,Maren Eggers,Lothar Kuehn,Tobias P. Dick,Hansjörg Schild,Hans-Georg Rammensee,Ulrich H. Koszinowski,Peter M. Kloetzel +8 more
TL;DR: Enhanced expression of PA28α at a level similar to that obtained after IFN-γ induction resulted in a marked enhancement of recognition by pp89-specific cytotoxic T cells; the presentation of influenza nucleoprotein was also significantly improved.
Journal ArticleDOI
Peptide antigen production by the proteasome: complexity provides efficiency
TL;DR: The structural architecture of the proteasome and its proteolytic mechanisms with respect to the generation of antigenic peptides are discussed and it is suggested that exchanges of proteolysis proteasomes subunits and proteasom activators cooperate to optimize the production of antigens for cytotoxic T cells.
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AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells.
Diego Gravotta,Ami A. Deora,Emilie Perret,Claudia Oyanadel,Andrea Soza,Ryan Schreiner,Alfonso González,Enrique Rodriguez-Boulan +7 more
TL;DR: The epithelial-specific adaptor AP1B sorts basolateral proteins in both biosynthetic and recycling routes of MDCK cells, as a result of its predominant functional localization in recycling endosomes, which constitute a post-Golgi station in the biosynthetics route of some plasma membrane proteins.
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Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
Katrin Schwarz,Maries van den Broek,Susanne Kostka,Regine Kraft,Andrea Soza,Gunter Schmidtke,Peter-M. Kloetzel,Marcus Groettrup +7 more
TL;DR: Evidence is provided that up-regulation of the three inducible subunits, LMP2, L MP7, and MECL-1, can result in a marked improvement of Ag presentation and that, depending on the epitope, PA28 and immunoproteasomes may differentially affect Ag processing.
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LMP-associated proteolytic activities and TAP-dependent peptide transport for class 1 MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12.
TL;DR: Ad12 viral transformation appears to suppress the expression of multiple genes that are important for antigen processing and presentation, which allows such transformed cells to escape immune surveillance.