Andrea Stoccoro

TL;DR: The aim of this review is to better clarify the mechanisms of the initiation and/or the promotion of arsenic-induced carcinogenesis in order to understand the best way to perform an early diagnosis and a prompt prevention that is the key point for protecting arsenic-exposed population.

TL;DR: This article summarizes the studies performed so far to evaluate the ability of certain nano-sized compounds to induce an impaired expression of genes involved inDNA methylation reactions leading to global DNA methylation changes, as well as changes of gene specific methylation of tumor suppressor genes, inflammatory genes, and DNA repair genes, all potentially involved in cancer development.

TL;DR: Overall, the new approach allows MS-HRM to be used as a quantitative assay which provides results which are comparable with those obtained by pyrosequencing.

TL;DR: Blood DNA data suggest that none of the studied regions is differently methylated in blood DNA between AD and control subjects, and no correlation with the studied biomarkers is suggested.

TL;DR: Overall, the present data indicate that there is a decreased methylation of the D-loop region in LOAD peripheral blood DNA, suggesting that mtDNA epimutations deserve further investigations in AD pathogenesis.