A
Andreas Fehrenbacher
Publications - 2
Citations - 637
Andreas Fehrenbacher is an academic researcher. The author has contributed to research in topics: Nicotinic agonist & Galantamine. The author has an hindex of 2, co-authored 2 publications receiving 618 citations.
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Journal ArticleDOI
Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors
Marek Samochocki,Anja Höffle,Andreas Fehrenbacher,Ruth Jostock,Jürgen Ludwig,Claudia Christner,Martin Radina,Marion Zerlin,Christoph Ullmer,Edna F. R. Pereira,Hermann Lübbert,Edson X. Albuquerque,Alfred Maelicke +12 more
TL;DR: These studies support the previous proposal that the therapeutic action of galantamine is mainly produced by its sensitizing action on nAChRs rather than by general cholinergic enhancement due to cholinesterase inhibition.
Journal ArticleDOI
Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease.
Alfred Maelicke,Marek Samochocki,Ruth Jostock,Andreas Fehrenbacher,Jürgen Ludwig,Edson X Albuquerque,Marion Zerlin +6 more
TL;DR: It is found that a subgroup of cholinesterase inhibitors, including galantamine but excluding tacrine, directly interacts with nicotinic acetylcholine receptors, and these compounds, named allosterically potentiating ligands, sensitize Nicotinic receptors by increasing the probability of channel opening induced by acetyl choline and nicotinics agonists and by slowing down receptor desensitization.