C
Christoph Ullmer
Researcher at Hoffmann-La Roche
Publications - 99
Citations - 5048
Christoph Ullmer is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Receptor & G protein-coupled bile acid receptor. The author has an hindex of 29, co-authored 93 publications receiving 4538 citations. Previous affiliations of Christoph Ullmer include Novartis.
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Journal ArticleDOI
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Andreas Kistner,Manfred Gossen,Frank Zimmermann,Jasna Jerecic,Christoph Ullmer,Hermann Lübbert,Hermann Bujard +6 more
TL;DR: Both tetracycline-controlled transcriptional activation systems provide genetic switches that permit the quantitative control of gene activities in transgenic mice in a tissue-specific manner and, thus, suggest possibilities for the generation of a novel type of conditional mutants.
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Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors
Marek Samochocki,Anja Höffle,Andreas Fehrenbacher,Ruth Jostock,Jürgen Ludwig,Claudia Christner,Martin Radina,Marion Zerlin,Christoph Ullmer,Edna F. R. Pereira,Hermann Lübbert,Edson X. Albuquerque,Alfred Maelicke +12 more
TL;DR: These studies support the previous proposal that the therapeutic action of galantamine is mainly produced by its sensitizing action on nAChRs rather than by general cholinergic enhancement due to cholinesterase inhibition.
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Expression of serotonin receptor mRNAs in blood vessels
TL;DR: Using RT‐PCR, mRNAs for all known G‐protein coupled serotonin receptors expressed in various rat and porcine blood vessels are distinguished and a model for the regulation of vascular tone by different 5‐HT receptors is proposed.
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The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
Verena Keitel,Kenko Cupisti,Christoph Ullmer,Wolfram T. Knoefel,Ralf Kubitz,Dieter Häussinger +5 more
TL;DR: A role for TGR5 in bile acid–induced fluid secretion in biliary epithelial cells is suggested, and the presence of the receptor in both the plasma membrane and the recycling endosome indicate that T GR5 can be regulated by translocation.
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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Marjolein Soethoudt,Uwe Grether,Juergen Fingerle,Travis W. Grim,Filomena Fezza,Luciano De Petrocellis,Christoph Ullmer,Benno Rothenhäusler,Camille Perret,Noortje van Gils,David B. Finlay,Christa MacDonald,Andrea Chicca,Marianela Dalghi Gens,Jordyn Stuart,Henk de Vries,Nicolina Mastrangelo,Lizi Xia,Georgios Alachouzos,Marc P. Baggelaar,Andrea Martella,Elliot D. Mock,Hui Deng,Laura H. Heitman,Mark Connor,Vincenzo Di Marzo,Jürg Gertsch,Aron H. Lichtman,Mauro Maccarrone,Pal Pacher,Michelle Glass,Mario van der Stelt +31 more
TL;DR: The most extensive characterization of the molecular pharmacology of the most widely used CB2R ligands to date is reported, identifying marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects.