Andreas Herrmann

TL;DR: Robust partitioning into lo phases was confirmed by using viral lipid mixtures and giant plasma membrane vesicles, and efficient protein targeting into lo and ld domains within the plasma membrane of living cells was demonstrated by single-molecule tracking, thus establishing a highly generic approach for exploring lipid microdomains in Situ.

TL;DR: An understanding of the physico-chemical parameters determining the local environment of the covalent-bond cleavage site is an important prerequisite to transfer the characteristics of small molecules to larger structures such as oligomers and polymers and thus to design efficient macromolecular conjugates for the controlled delivery of bioactive compounds.

TL;DR: Together, the data suggest similar conformational changes during the transport cycle as described for the maltose ABC transporter of Escherichia coli, despite distinct structural differences between both systems.

TL;DR: Taken together, the otherwise clinically approved UBKIs regorafenib and sorafenIB possess high and broad-spectrum antiviral activity along with substantial robustness against resistance development and thus constitute attractive host-directed drug candidates against a range of viral infections including influenza.

TL;DR: The results show that the combination of FLIM and ITIR-FCS with specific fluorescent lipid analogs is a powerful tool for investigating lateral and transbilayer characteristics of plasma membrane in live cell lines.