Andreas Hombach

TL;DR: T cells grafted with the combined CD28/CD3ζ signaling receptor secreted high amounts of IL-2 upon Ag binding without exogenous B7/CD28 costimulation, demonstrating that both MHC-independent cellular activation and CD28costimulation for complete T cell activation can be delivered by one recombinant receptor molecule.

TL;DR: Rec recombinant immunoreceptors of higher affinity do not necessarily induce a more potent activation of T cells than low affinity immunoreCEPTors, but the higher affinity immunoresceptors exhibit less discrimination between target cells with high or low Ag expression levels.

TL;DR: EBV-CTLs expressing both a native and a chimeric antigen receptor may have added value for treatment of HD, and could be costimulated by EBV-infected cells and produce antitumor effects even against EBV(-)/CD30(+) tumors.

TL;DR: It is revealed that CARs with Fc spacer domain bind to IgG Fc gamma receptors (FcγRs), thereby unintentionally activating innate immune cells, including monocytes and natural killer cells, which consequently secrete high amounts of pro-inflammatory cytokines.

TL;DR: The histologic evidence of dysplasia was shown to be a strong indicator of underlying carcinoma or developing malignant transformation, and the role of surveillance programs for the early detection of ulcerative colitis associated colorectal cancer at a curable stage is still under debate.