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Andrew A. Dwyer
Researcher at Boston College
Publications - 148
Citations - 8028
Andrew A. Dwyer is an academic researcher from Boston College. The author has contributed to research in topics: Hypogonadotropic hypogonadism & Kallmann syndrome. The author has an hindex of 40, co-authored 131 publications receiving 6892 citations. Previous affiliations of Andrew A. Dwyer include University Hospital of Lausanne & Harvard University.
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Journal ArticleDOI
Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment
Ulrich Boehm,Pierre Bouloux,Mehul T. Dattani,Nicolas de Roux,Catherine Dodé,Leo Dunkel,Andrew A. Dwyer,Paolo Giacobini,J.-P. Hardelin,Anders Juul,Mohamad Maghnie,Nelly Pitteloud,Vincent Prevot,Taneli Raivio,Manuel Tena-Sempere,Richard Quinton,Jacques Young +16 more
TL;DR: A timely diagnosis and treatment to induce puberty can be beneficial for sexual, bone and metabolic health, and might help minimize some the psychological effects of CHH.
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Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men.
Nelly Pitteloud,Megan Hardin,Andrew A. Dwyer,Elena Valassi,Maria A Yialamas,Dariush Elahi,Dariush Elahi,Frances J. Hayes +7 more
TL;DR: It is concluded that insulin resistance is associated with a decrease in Leydig cell T secretion in men with a spectrum of insulin sensitivity.
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Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men
Nelly Pitteloud,Vamsi K. Mootha,Andrew A. Dwyer,Megan Hardin,Hang Lee,Karl-Fredrik Eriksson,Devjit Tripathy,Maria A Yialamas,Leif Groop,Dariush Elahi,Frances J. Hayes +10 more
TL;DR: These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men.
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Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice
John L. Falardeau,Wilson C. J. Chung,Andrew Beenken,Taneli Raivio,Lacey Plummer,Yisrael Sidis,Elka Jacobson-Dickman,Anna V. Eliseenkova,Jinghong Ma,Andrew A. Dwyer,Richard Quinton,Sandra Na,Janet E. Hall,Céline Huot,Natalie Alois,Simon H. S. Pearce,Lindsay W. Cole,Virginia A. Hughes,Moosa Mohammadi,Pei Tsai,Nelly Pitteloud +20 more
TL;DR: FGF8 is identified as a gene implicated in GnRH deficiency in both humans and mice and demonstrated an exquisite sensitivity of GnRH neuron development to reductions in FGF8 signaling.
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Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism
Nelly Pitteloud,Richard Quinton,Simon H. S. Pearce,Taneli Raivio,James S. Acierno,Andrew A. Dwyer,Lacey Plummer,Virginia A. Hughes,Stephanie B. Seminara,Yu-Zhu Cheng,Wei-Ping Li,Gavin MacColl,Anna V. Eliseenkova,Shaun K. Olsen,Omar A. Ibrahimi,Frances J. Hayes,Paul A. Boepple,Janet E. Hall,Pierre Bouloux,Moosa Mohammadi,William F. Crowley +20 more
TL;DR: 2 different gene defects can synergize to produce a more severe phenotype in IHH families than either alone, and this genetic model could account for some phenotypic heterogeneity seen in GnRH deficiency.