A
Andrew G. Leach
Researcher at University of Manchester
Publications - 147
Citations - 5474
Andrew G. Leach is an academic researcher from University of Manchester. The author has contributed to research in topics: Protein ligand & Ene reaction. The author has an hindex of 34, co-authored 139 publications receiving 4819 citations. Previous affiliations of Andrew G. Leach include University of California, Los Angeles & University of Leeds.
Papers
More filters
Journal ArticleDOI
Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation
Steven V. Ley,Ian R. Baxendale,Robert N. Bream,Philip S. Jackson,Andrew G. Leach,Deborah A. Longbottom,Marcella Nesi,James S. Scott,R. Ian Storer,Stephen Taylor +9 more
TL;DR: A review of solid-phase organic synthesis can be found in this article, where the authors discuss the use of reagents and scavenging reagents in the context of solid phase organic synthesis (SPOS).
Journal ArticleDOI
Binding Affinities of Host–Guest, Protein–Ligand, and Protein–Transition‐State Complexes
TL;DR: The origins of the distributions of association constants observed for the broad range of host-guest systems are explored, and typical approaches to compute and analyze host-GUest binding in solution are discussed.
Journal ArticleDOI
A Standard Set of Pericyclic Reactions of Hydrocarbons for the Benchmarking of Computational Methods: The Performance of ab Initio, Density Functional, CASSCF, CASPT2, and CBS-QB3 Methods for the Prediction of Activation Barriers, Reaction Energetics, and Transition State Geometries
Vildan Güner,Kelli S. Khuong,Andrew G. Leach,Patrick Lee,Michael D. Bartberger,Kendall N. Houk +5 more
TL;DR: In this article, experimental and theoretical data are provided for a set of 11 pericyclic reactions of unsaturated hydrocarbons, and experimental data are evaluated and standardized to ΔH⧧ 0K for comparison to theory.
Journal ArticleDOI
Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.
Andrew G. Leach,H. Jones,David A. Cosgrove,Peter W. Kenny,Linette Ruston,Philip A. MacFaul,J. Matthew Wood,Nicola Colclough,Brian Law +8 more
TL;DR: The effects on aqueous solubility, plasma protein binding and oral exposure of adding substituents to aromatic rings and methylating heteroatoms are focused upon.
Journal ArticleDOI
Protodeboronation of Heteroaromatic, Vinyl, and Cyclopropyl Boronic Acids: pH-Rate Profiles, Autocatalysis, and Disproportionation.
TL;DR: pH-rate profiles for aqueous-organic protodeboronation of 18 boronic acids, many widely viewed as unstable, have been studied by NMR and DFT and can be correlated as a function of pH (1-13) for all 18 species.