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Andrew Hugin Thompson
Publications - 10
Citations - 338
Andrew Hugin Thompson is an academic researcher. The author has contributed to research in topics: Analyte & Mass spectrometry. The author has an hindex of 5, co-authored 10 publications receiving 185 citations.
Papers
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Journal ArticleDOI
TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples.
Jiaming Li,Jonathan G. Van Vranken,Laura Pontano Vaites,Devin K. Schweppe,Edward L. Huttlin,Chris Etienne,Premchendar Nandhikonda,Rosa Viner,Aaron M. Robitaille,Andrew Hugin Thompson,Karsten Kuhn,Ian Pike,Ryan Bomgarden,John C. Rogers,Steven P. Gygi,Joao A. Paulo +15 more
TL;DR: A set of isobaric labeling reagents called TMTpro enables deep quantitative comparisons of proteome measurements across 16 samples, and identifies and dose-stratified staurosporine binding to 228 cellular kinases in just one, 18-h experiment.
Journal ArticleDOI
Low-pH Solid-Phase Amino Labeling of Complex Peptide Digests with TMTs Improves Peptide Identification Rates for Multiplexed Global Phosphopeptide Analysis
Gitte Böhm,Petra Prefot,Stephan Jung,Stefan Selzer,Vikram Mitra,David Britton,Karsten Kuhn,Ian Pike,Andrew Hugin Thompson +8 more
TL;DR: A novel tandem mass tag solid-phase amino labeling (TMT-SPAL) protocol using reversible immobilization of peptides onto octadecyl-derivatized (C18) solid supports is presented, which can reduce the number of steps required in complex protocols, saving time and potentially reducing sample loss.
Patent
Method for characterizing polypeptides
Christian Hamon,Andrew Hugin Thompson,Thomas Neumann,Robert Alexander Walker Johnstone,Abdul Karim Abed Mohammed +4 more
TL;DR: In this article, the authors proposed a method for characterising a polypeptide, which comprises the steps of: (a) optionnally reducing cysteine disulphide bridges in the poly peptide to form free thiols, and capping the free THiols; (b) cleaving the polypeptic with a sequence specific cleavage reagent to form peptide fragments; (c) optionally deactivating the cleaving reagent; (d) capping one or more e-amino groups that are present with a lys
Patent
Mass markers and methods
TL;DR: In this paper, the authors describe compounds useful for labeling molecules of interest (i.e. analytes), particularly biomolecules such as peptides, proteins, oligonucleotides and nucleic acids, and also methods for analysing, detecting and/or isolating these labelled molecules using mass spectrometry.
Patent
Method for characterising analytes
Andrew Hugin Thompson,Christian Hamon,Karsten Kuhn,Markus Meyer,Schafer Juergen,Thomas Neumann +5 more
TL;DR: In this article, a matrix assisted matrix assisted laser desorption ionisation (MALDI) mass spectrometry method is proposed to characterise an analyte by matrix assisted mass spectroscopy.