I
Ian Pike
Researcher at University of Eastern Finland
Publications - 61
Citations - 2455
Ian Pike is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Proteomics & Tandem mass tag. The author has an hindex of 21, co-authored 60 publications receiving 1851 citations. Previous affiliations of Ian Pike include King's College London & University of Leeds.
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Journal ArticleDOI
Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses.
Graeme C. McAlister,Edward L. Huttlin,Wilhelm Haas,Lily Ting,Mark P. Jedrychowski,John C. Rogers,Karsten Kuhn,Ian Pike,Robert A. Grothe,Justin D. Blethrow,Steven P. Gygi +10 more
TL;DR: This work serves as a blueprint for expanding the multiplexing capacity of the TMT reagents to at least 10-plex and possibly up to 18-plex, and is able to quantify across eight samples simultaneously by combining the (13)C- and (15)N-containing reporter ions.
Journal ArticleDOI
TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples.
Jiaming Li,Jonathan G. Van Vranken,Laura Pontano Vaites,Devin K. Schweppe,Edward L. Huttlin,Chris Etienne,Premchendar Nandhikonda,Rosa Viner,Aaron M. Robitaille,Andrew Hugin Thompson,Karsten Kuhn,Ian Pike,Ryan Bomgarden,John C. Rogers,Steven P. Gygi,Joao A. Paulo +15 more
TL;DR: A set of isobaric labeling reagents called TMTpro enables deep quantitative comparisons of proteome measurements across 16 samples, and identifies and dose-stratified staurosporine binding to 228 cellular kinases in just one, 18-h experiment.
Journal ArticleDOI
Plasma proteins predict conversion to dementia from prodromal disease
Abdul Hye,Joanna Riddoch-Contreras,Alison L. Baird,Nicholas J. Ashton,Chantal Bazenet,Rufina Leung,Eric Westman,Eric Westman,Andrew Simmons,Richard Dobson,Martina Sattlecker,Michelle K. Lupton,Michelle K. Lupton,Katie Lunnon,Aoife Keohane,Malcolm Ward,Ian Pike,Hans Dieter Zucht,Danielle Pepin,Wei Zheng,Alan Tunnicliffe,Jill C. Richardson,Serge Gauthier,Hilkka Soininen,Iwona Kłoszewska,Patrizia Mecocci,Magda Tsolaki,Bruno Vellas,Simon Lovestone,Simon Lovestone +29 more
TL;DR: The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.
Journal ArticleDOI
Use of NS-4 peptides to identify type-specific antibody to hepatitis C virus genotypes 1, 2, 3, 4, 5 and 6.
V Bhattacherjee,L E Prescott,Ian Pike,B Rodgers,H Bell,Abdel-Rahman El-Zayadi,M C Kew,J Conradie,C. K. Lin,H. Marsden,A A Saeed,D Parker,P L Yap,Peter Simmonds +13 more
TL;DR: The existence of major antigenic differences between genotypes ofHCV is demonstrated, and how infection with different variants of HCV may be detected by a serological test is indicated.
Journal ArticleDOI
TMTpro: Design, Synthesis, and Initial Evaluation of a Proline-Based Isobaric 16-Plex Tandem Mass Tag Reagent Set
Andrew J. Thompson,Nikolai Wölmer,Sasa Koncarevic,Stefan Selzer,Gitte Böhm,Harald Legner,Peter Schmid,Stefan Kienle,Petra Penning,Claudia Höhle,Antje Berfelde,Roxana Martinez-Pinna,V. M. Farztdinov,Stephan Jung,Karsten Kuhn,Ian Pike +15 more
TL;DR: The ability to pool 16 samples reduces the overall amount of sample required for each channel and it is anticipated that TMTpro reagents will be a useful enhancement for any protocol that benefits from sample pooling and should reduce missing data.