Andrew J. Ghio

TL;DR: Results of studies conducted to identify constituents responsible for the acute lung injury induced by residual oil fly ash (ROFA) and to assess physical-chemical factors that influence the pulmonary toxicity of these constituents provide direct evidence for the role of soluble transition metals in the pulmonary injuryinduced by the combustion emission source particulate, ROFA.

TL;DR: It is concluded that PM causes AEC DNA damage and apoptosis by mechanisms that involve the mitochondria-regulated death pathway and the generation of iron-derived free radicals.

TL;DR: A flow cytometry panel in human BAL and lung tissue is defined that allows identification of multiple immune cell types and delineates alveolar from interstitial-associated macrophages and has important implications for defining myeloid cells in human lung samples.

TL;DR: It is concluded that cigarette smoke particles alter iron homeostasis, both in the lung and systemically, as well as in healthy smokers and smoking patients with chronic obstructive pulmonary disease.

TL;DR: The LCL response of PMN in general increased with all washed particles, and results point to the possibility that the insoluble constituents of the particles are related to LCL in PMN.