Andrew J. Watson

TL;DR: In this paper, five predominant mineral phases have been identified (calcite, aragonite, celestite, barite and opaline silica), which are progressively dissolved from the settling particulate matter and consequently influence the vertical distribution not only of their major constituent elements (Ca, Ba, Sr, C, Si) but also of a range of trace elements (Ge, Se, Zn, Sc, Cr, Be, Cu, Ni).

TL;DR: Blockage of p38 MAPK activity is associated with embryo stage specific influences on Trp53, Ppm1d, Cdkn2a, and Mapk14 expression during mouse preimplantation development, and results indicate that the p38MAPK pathway regulates Trp 53, PPM1D, and CdKn2a expression.

TL;DR: This study implicates SNAi1 and SNAI2 in the lineage segregation of the trophectoderm and inner cell mass, and provides new insight into these oncogenes.

TL;DR: The analysis of the crystal structure of ligand‐free and 2R‐sialic acid alditol‐bound MRSA N‐acetylneuraminate lyase suggests that subtle dynamic differences in solution and/or altered binding interactions within the active site may account for species‐specific inhibition.

TL;DR: The results indicate that early embryonic AMPK levels must be tightly regulated to ensure normal preimplantation development and blastocyst formation to occur and use of metformin should be carefully considered during preIMplantation and early post-embryo transfer phases of fertility treatment cycles.