A
Andrew L. Doedens
Researcher at University of California, San Diego
Publications - 25
Citations - 4830
Andrew L. Doedens is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 20, co-authored 25 publications receiving 4104 citations. Previous affiliations of Andrew L. Doedens include Indiana University & University of Edinburgh.
Papers
More filters
Journal ArticleDOI
HIF-1α expression regulates the bactericidal capacity of phagocytes
Carole Peyssonnaux,Vivekanand Datta,Thorsten Cramer,Andrew L. Doedens,Emmanuel A. Theodorakis,Richard L. Gallo,Nancy Hurtado-Ziola,Victor Nizet,Randall S. Johnson +8 more
TL;DR: HIF-1alpha was induced by bacterial infection, even under normoxia, and regulated the production of key immune effector molecules, including granule proteases, antimicrobial peptides, nitric oxide, and TNF-alpha.
Journal ArticleDOI
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Andrew L. Doedens,Christian Stockmann,Mark P. Rubinstein,Debbie Liao,Na Zhang,David G. DeNardo,Lisa M. Coussens,Michael Karin,Ananda W. Goldrath,Randall S. Johnson +9 more
TL;DR: It is found that hypoxia powerfully augmented macrophage-mediated T-cell suppression in vitro in a manner dependent on macrophages expression of HIF-1α, which links the innate immune hypoxic response to tumor progression through induction of T- cell suppression in the tumor microenvironment.
Journal ArticleDOI
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
Norihiko Takeda,Ellen O'Dea,Andrew L. Doedens,Jung Whan Kim,Alexander Weidemann,Christian Stockmann,Masataka Asagiri,M. Celeste Simon,Alexander Hoffmann,Randall S. Johnson +9 more
TL;DR: The studies reveal that the two homologous transcription factors, Hif-1alpha and HIF-2alpha, can have physiologically antagonistic functions, but that their antiphase regulation allows them to coordinately regulate NO production in a cytokine-induced and transcription-dependent fashion.
Journal ArticleDOI
Hypoxia-inducible factors enhance the effector responses of CD8 + T cells to persistent antigen
Andrew L. Doedens,Anthony T. Phan,Martin H Stradner,Martin H Stradner,Jessica K Fujimoto,Jessica V. Nguyen,Edward Yang,Randall S. Johnson,Ananda W. Goldrath +8 more
TL;DR: It is found that HIFs and oxygen influenced the expression of pivotal transcription, effector and costimulatory-inhibitory molecules of CTLs, which was relevant to strategies that promote the clearance of viruses and tumors.
Journal ArticleDOI
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
Christian Stockmann,Andrew L. Doedens,Alexander Weidemann,Na Zhang,Norihiko Takeda,Joshua I. Greenberg,David A. Cheresh,Randall S. Johnson +7 more
TL;DR: Deletion of myeloid-cell VEGF-A resulted in an accelerated tumour progression in multiple subcutaneous isograft models and an autochthonous transgenic model of mammary tumorigenesis, with less overall tumour cell death and decreased tumour hypoxia.