Andrew Needles

TL;DR: Current concepts and future directions of molecular ultrasound imaging are reviewed, including different classes of molecular ultrasounds contrast agents, ongoing technical developments of pre-clinical and clinical ultrasound systems, the potential of Molecular ultrasound for imaging different diseases at the molecular level, and the translation of molecular Ultrasound into the clinic.

TL;DR: The first commercially available array transducer-based ultrasound imaging system that enables micro-ultrasound imaging at center frequencies between 15 and 50 MHz is reported, and the unprecedented images made with the new imaging system will enable many new applications not previously possible.

TL;DR: The development of nonlinear microbubble B-scan imaging instrumentation capable of operating at transmit center frequencies between 10 and 50 MHz and the successful detection of microvessels in the rabbit ear and in the mouse heart is described.

TL;DR: Beamforming techniques and signal processing are described, in conjunction with in vivo PA images of normal subcutaneous mouse tissue and selected tumor models, and the use of the system to estimate the spatial distribution of oxygen saturation in blood and co-registered with B-mode images of the surrounding anatomy is investigated.

TL;DR: In vivo parametric images of murine kidneys were generated using sequences of nonlinear contrast images after intravenous bolus injections of microbubble suspensions, indicative of blood perfusion kinetics, which are anticipated to provide valuable insights into the progression of human disease models.