A
Andrew Sobala
Researcher at King's College London
Publications - 11
Citations - 1348
Andrew Sobala is an academic researcher from King's College London. The author has contributed to research in topics: Small RNA & RNA. The author has an hindex of 7, co-authored 11 publications receiving 1176 citations. Previous affiliations of Andrew Sobala include University of Dundee.
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Journal ArticleDOI
Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs
Christian Cole,Andrew Sobala,Cheng Lu,Shawn R. Thatcher,Andrew Bowman,John W. S. Brown,Pamela J. Green,Geoffrey J. Barton,Gyorgy Hutvagner +8 more
TL;DR: It is shown that the processing of small RNAs derived from tRNA(Gln) is dependent on Dicer in vivo and that Dicer cleaves the tRNA in vitro.
Journal ArticleDOI
Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells
Andrew Sobala,Gyorgy Hutvagner +1 more
TL;DR: Evidence is presented that conserved residues in tRNA, present in all 5′ tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA.
Journal ArticleDOI
Transfer RNA-derived fragments: origins, processing, and functions
TL;DR: This review focuses on a recently identified group of small RNAs that are derived from transfer RNAs, tRNA fragments (tRFs), and proposes a nomenclature that is based on their processing characteristics.
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HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells.
TL;DR: The cancer drug geldanamycin, an HSP90 inhibitor, decreases the stability of key components of the miRNA regulatory pathway, the efficacy of siRNAs, and the formation of P-bodies without affecting endogenous miRNA function.
Journal ArticleDOI
Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G
Darja Pollpeter,Maddy Parsons,Andrew Sobala,Sashika Coxhead,Rupert D. Lang,Annie M. Bruns,Stelios Papaioannou,James M. McDonnell,Luis Apolonia,Jamil A. Chowdhury,Curt M. Horvath,Michael H. Malim +11 more
TL;DR: A deep sequencing strategy is developed to characterize nascent reverse transcription products and their precise 3′-termini in HIV-1 infected T cells, and site- and sequence-independent interference with reverse transcription is demonstrated, which requires the specific interaction of A3G with reverse transcriptase itself.