C
Cheng Lu
Researcher at Delaware Biotechnology Institute
Publications - 282
Citations - 7771
Cheng Lu is an academic researcher from Delaware Biotechnology Institute. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 20, co-authored 33 publications receiving 6437 citations. Previous affiliations of Cheng Lu include DuPont & Pennsylvania State University.
Papers
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Journal ArticleDOI
Global identification of microRNA-target RNA pairs by parallel analysis of RNA ends.
Marcelo A German,Manoj Pillay,Dong-Hoon Jeong,Amit Hetawal,Shujun Luo,Prakash E. Janardhanan,Vimal Kannan,Linda A. Rymarquis,Kan Nobuta,Rana German,Emanuele De Paoli,Cheng Lu,Gary P. Schroth,Blake C. Meyers,Pamela J. Green +14 more
TL;DR: Working in reverse from the cleaved targets resulted in the identification and validation of novel miRNAs, which will affect the study of other aspects of RNA processing beyond miRNA–target RNA pairs.
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Elucidation of the small RNA component of the transcriptome.
Cheng Lu,Shivakundan Singh Tej,Shujun Luo,Christian D. Haudenschild,Blake C. Meyers,Blake C. Meyers,Pamela J. Green,Pamela J. Green +7 more
TL;DR: Many genomic regions previously considered featureless were found to be sites of numerous small RNAs, and known and new microRNAs were among the most abundant of the nonredundant set of more than 75,000 sequences.
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Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning
Ian R. Henderson,Xiaoyu Zhang,Cheng Lu,Lianna M. Johnson,Blake C. Meyers,Pamela J. Green,Steven E. Jacobsen +6 more
TL;DR: Sequencing of small RNAs from a dcl2 dcl3 dcl4 triple mutant showed markedly reduced tasiRNA and siRNA production and indicated that DCL1, in addition to its role as the major enzyme for processing miRNAs, has a previously unknown role in the production of smallRNAs from endogenous inverted repeats.
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Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs
Christian Cole,Andrew Sobala,Cheng Lu,Shawn R. Thatcher,Andrew Bowman,John W. S. Brown,Pamela J. Green,Geoffrey J. Barton,Gyorgy Hutvagner +8 more
TL;DR: It is shown that the processing of small RNAs derived from tRNA(Gln) is dependent on Dicer in vivo and that Dicer cleaves the tRNA in vitro.
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Nitrate-responsive miR393/AFB3 regulatory module controls root system architecture in Arabidopsis thaliana.
Elena A. Vidal,Viviana Araus,Cheng Lu,Geraint Parry,Pamela J. Green,Gloria M. Coruzzi,Rodrigo A. Gutiérrez +6 more
TL;DR: Interestingly, regulation of RSA by nitrate was specifically mediated by AFB3, indicating that miR393/AFB3 is a unique N-responsive module that controls root system architecture in response to external and internal N availability in Arabidopsis.