R
Ronald T. Hay
Researcher at University of Dundee
Publications - 260
Citations - 29175
Ronald T. Hay is an academic researcher from University of Dundee. The author has contributed to research in topics: SUMO protein & Ubiquitin. The author has an hindex of 89, co-authored 255 publications receiving 27391 citations. Previous affiliations of Ronald T. Hay include Medical Research Council & University of St Andrews.
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Journal ArticleDOI
SUMO: a history of modification
TL;DR: The diverse effects of SUMO modification are discussed and models proposed to explain SUMO actions.
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SUMO-1 Modification of IκBα Inhibits NF-κB Activation
TL;DR: In this article, a modified IkappaBalpha, conjugated to the small ubiquitin-like protein SUMO-1, which is resistant to signal-induced degradation, was detected.
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Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9
Michael H. Tatham,Ellis Jaffray,Owen A. Vaughan,Joana M. P. Desterro,Catherine H. Botting,James H. Naismith,Ronald T. Hay +6 more
TL;DR: The ability to form polymeric chains is not shared by SUMO-1, and although all SUMO species use the same conjugation machinery, modification by SUMo-1 andsumO-2/-3 may have distinct functional consequences.
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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
Michael H. Tatham,Marie-Claude Geoffroy,Linnan Shen,Anna Plechanovová,Neil Hattersley,Ellis Jaffray,Jorma J. Palvimo,Ronald T. Hay +7 more
TL;DR: It is demonstrated that poly-SUMO chains can act as discrete signals from mono-SumOylation, in this case targeting a poly- SUMOylated substrate for ubiquitin-mediated proteolysis.
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Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62.
TL;DR: Modification of p50 by thioredoxin, a gene induced by stimulation of T-lymphocytes in parallel with NF-kappa B translocation, is a likely step in the cascade of events leading to full NF- kappa B activation.