G
Gyorgy Hutvagner
Researcher at University of Technology, Sydney
Publications - 78
Citations - 16608
Gyorgy Hutvagner is an academic researcher from University of Technology, Sydney. The author has contributed to research in topics: microRNA & RNA interference. The author has an hindex of 36, co-authored 74 publications receiving 15628 citations. Previous affiliations of Gyorgy Hutvagner include University of Massachusetts Medical School & University of Massachusetts Boston.
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Journal ArticleDOI
Asymmetry in the assembly of the RNAi enzyme complex.
TL;DR: It is shown that the two strands of an siRNA duplex are not equally eligible for assembly into RISC, and it is suggested that single-stranded miRNAs are initially generated as siRNA-like duplexes whose structures predestine one strand to enter the RISC and the other strand to be destroyed.
Journal ArticleDOI
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.
Gyorgy Hutvagner,Juanita Mclachlan,Amy E. Pasquinelli,Eva Balint,Thomas Tuschl,Phillip D. Zamore +5 more
TL;DR: In Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let-7 stRNA, which regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals.
Journal ArticleDOI
A microRNA in a multiple-turnover RNAi enzyme complex.
TL;DR: It is shown that, in human cell extracts, the miRNA let-7 naturally enters the RNAi pathway, which suggests that only the degree of complementarity between a miRNA and its RNA target determines its function.
Journal ArticleDOI
Argonaute proteins: key players in RNA silencing
TL;DR: This work has shown that Argonaute proteins, a highly conserved protein family, can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs.
PatentDOI
Sequence-specific inhibition of small RNA function
TL;DR: The RISC inactivators of the present invention enable a variety of methods for identifying and characterizing miRNAs and siRNAs, RISC-associated factors, and agents capable of modulating RNA silencing.