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Andrey A. Tolmachev
Researcher at Enamine Ltd
Publications - 278
Citations - 2773
Andrey A. Tolmachev is an academic researcher from Enamine Ltd. The author has contributed to research in topics: Catalysis & Alkylation. The author has an hindex of 23, co-authored 275 publications receiving 2258 citations. Previous affiliations of Andrey A. Tolmachev include National Academy of Sciences of Ukraine & Taras Shevchenko National University of Kyiv.
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Journal ArticleDOI
Ultra-large library docking for discovering new chemotypes
Jiankun Lyu,Sheng Wang,Trent E. Balius,Isha Singh,Anat Levit,Yurii S. Moroz,Matthew J. O’Meara,Tao Che,Enkhjargal Algaa,Kateryna A. Tolmachova,Andrey A. Tolmachev,Brian K. Shoichet,Bryan L. Roth,John J. Irwin +13 more
TL;DR: Using a make-on-demand library that contains hundreds-of-millions of molecules, structure-based docking was used to identify compounds that, after synthesis and testing, are shown to interact with AmpC β-lactamase and the D4 dopamine receptor with high affinity.
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Bicyclic Conformationally Restricted Diamines
Oleksandr O. Grygorenko,Oleksandr O. Grygorenko,Dmytro S. Radchenko,Dmytro S. Radchenko,Dmitriy M. Volochnyuk,Andrey A. Tolmachev,Andrey A. Tolmachev,Igor V. Komarov,Igor V. Komarov +8 more
TL;DR: In this paper, the authors propose a method to solve the problem of the problem: this paper...,.. ].. ).. ]... )...
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Combinatorial Knoevenagel reactions.
Sergey V. Ryabukhin,Andrey S. Plaskon,Dmitriy M. Volochnyuk,Sergey E. Pipko,Alexander Shivanyuk,Andrey A. Tolmachev +5 more
TL;DR: Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds.
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“Reported, but Still Unknown.” A Closer Look into 3,4-Bis- and 3,4,5-Tris(trifluoromethyl)pyrazoles
I. I. Gerus,Roman X. Mironetz,Ivan S. Kondratov,Andrei V. Bezdudny,Andrei V. Bezdudny,Yurii V. Dmytriv,Yurii V. Dmytriv,Oleg V. Shishkin,Viktoriia S. Starova,Olga A. Zaporozhets,Andrey A. Tolmachev,Andrey A. Tolmachev,Pavel K. Mykhailiuk,Pavel K. Mykhailiuk +13 more
TL;DR: The elaborated synthetic protocols allow gram-scale preparation of the target products and the obtained compounds are comprehensively characterized by means of crystallographic analysis, determination of pK(a) values and fluorescence measurements.
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Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery
Olexiy S. Artamonov,Evgeniy Y. Slobodyanyuk,Dmitriy M. Volochnyuk,Igor V. Komarov,Andrey A. Tolmachev,Andrey A. Tolmachev,Pavel K. Mykhailiuk,Pavel K. Mykhailiuk +7 more
TL;DR: In this article, five CF3-substituted 3-azabicyclo[n.1.0]alkanes were synthesized by CuCl-mediated trifluoromethylcyclopropanation reaction of the corresponding cyclic enamides with CF3CHN2.